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Envarsus XR (Tacrolimus)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


ENVARSUS XR is a prescription medication given to people who have received a kidney transplant. It prevents the rejection of organ donation.

ENVARSUS XR is an extended-release version of tacrolimus, and patients may be converted to this formulation to take fewer doses per day.


Take at the same time each day on an empty stomach. 

Take exactly as directed by your doctor. Your doctor will determine the starting dose and it will change based on blood levels.


The active ingredient in ENVARSUS XR is tacrolimus.


ENVARSUS XR has many drug interactions that can cause harmful effects. Some drugs can increase ENVARSUS XR levels dangerously high, resulting in toxic side effects. Other medications may decrease ENVARSUS XR levels, leading to organ rejection. Speak with your doctor and pharmacist before starting or changing any medications.

Examples of drug interactions include:

  • Alcohol
  • Amiodarone
  • Anticonvulsants
  • Azole antifungals
  • Boceprevir
  • Carbamazepine
  • Chloramphenicol
  • Cimetidine
  • Clarithromycin
  • Diltiazem
  • Ethinyl Estradiol
  • Danazol
  • Lansoprazole
  • Magnesium and aluminum antacids
  • Methylprednisolone
  • Metoclopramide
  • Mycophenolic acid
  • Nefazodone
  • Nelfinavir
  • Nicardipine
  • Nifedipine
  • Omeprazole
  • Phenobarbital
  • Prednisone
  • Rifabutin
  • Rifampin
  • Ritonavir
  • St. John's Wort
  • Telaprevir
  • Troleandomycin
  • Verapamil


Do not drink grapefruit just while taking ENVARSUS XR because it can increase blood levels and the risk of serious adverse reactions.

Never change your formulation or dispensing pharmacy for ENVARSUS XR without talking with your physician. Even small variations in the levels of ENVARSUS XR in the blood cause lead to organ rejection or death. Therefore, it is important for your doctor to monitor you very closely if you switch formulations.

Do not get live vaccinations unless directed by your physician.

Tell your doctor if you have a history of:

  • Diabetes
  • Hyperkalemia
  • Hypertension
  • Neurotoxicity
  • QT prolongation

Side Effects

ENVARSUS XR side effects may include:

  • Anemia
  • Constipation
  • Diabetes Mellitus
  • Diarrhea
  • Headache
  • Hyperkalemia
  • Hypertension
  • Increased blood creatinine
  • Peripheral edema
  • Tremor
  • Urinary tract infection


Envarsus XR [package insert]. Cary, NC: Veloxis Pharmaceuticals; 2018.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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