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Entresto (Sacubitril/Valsartan)

Also Known as Vymada

Prescription medicineOnly Available By Prescription
Sezzle

Top brand choice

Strength Pack Size Qty
Strength
24mg/26mg
Pack Size
Qty
Strength
49mg/51mg
Pack Size
Qty
Strength
97mg/103mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
Strength
24mg/26mg
Pack Size
Qty
Strength
49mg/51mg
Pack Size
Qty
Strength
97mg/103mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

ENTRESTO is a prescription medicine used to reduce the risk of death and hospitalization in people with certain types of long-lasting (chronic) heart failure. ENTRESTO is usually used with other heart failure therapies, in place of an ACE inhibitor or other ARB therapy.

Fact Table

Formula

C96H120N12Na6O21

License

EU EMA

Bioavailability

60%

Legal status

US: RX Only

Chemical Name

Sacubitril / Valsartan

Elimination half-life

1.4-11 hours

Dosage (Strength)

24/25mg (56 or 168 tablets), 49/51mg (56 or 168 tablets), 97/103mg (56 or 168 tablets)

Pregnancy

Consult a doctor

Brands

Entresto

Protein binding

97%

PubChem CID

71449007

MedlinePlus

a682462

ChEBI

-

ATC code

C09DX04

DrugBank

DB09292, DB00177

KEGG

D10226

Routes of administration

By mouth (tablets)

Directions

The recommended starting dose of Entresto is one tablet of 49 mg/51 mg twice daily, except in certain situations. The dose should be doubled at 2-4 weeks to the target dose of one tablet of 97 mg/103 mg twice daily, as tolerated by the patient. Entresto may be administered with or without food. The tablets must be swallowed with a glass of water.

Ingredients

Each film-coated tablet contains sacubitril and valsartan (as sacubitril valsartan sodium salt complex) as active ingredients.

Cautions

Do not take ENTRESTO if you: 1)are allergic to sacubitril or valsartan or any of the ingredients in ENTRESTO 2)have had an allergic reaction including swelling of your face, lips, tongue, throat (angioedema) or trouble breathing while taking a type of medicine called an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB) 3)take an ACE inhibitor medicine. Do not take ENTRESTO for at least 36 hours before or after you take an ACE inhibitor medicine. Talk with your doctor or pharmacist before taking ENTRESTO if you are not sure if you take an ACE inhibitor medicine have diabetes and take a medicine that contains aliskiren

Side Effects

ENTRESTO may cause serious side effects including: angioedema that may cause trouble breathing and death. Get emergency medical help right away if you have symptoms of angioedema or trouble breathing. Do not take ENTRESTO again if you have had angioedema while taking ENTRESTO. People who are Black or who have had angioedema and take ENTRESTO may have a higher risk of having angioedema low blood pressure (hypotension). Call your doctor if you become dizzy or lightheaded, or you develop extreme fatigue kidney problems increased amount of potassium in your blood The most common side effects were low blood pressure, high potassium, cough, dizziness, and kidney problems.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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