Elestrin (Estradiol)

Prescription medicineOnly Available By Prescription

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Strength Pack Size Qty
0.06% 52g Gel
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Elestrin is gel that contains an estrogen, estradiol, to treat moderate to severe hot flashes in women with menopause

Fact Table






more than 5%

Legal status


Chemical Name


Elimination half-life

13–20 hours

Dosage (Strength)

0.06% 52g Gel


Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration



Elestrin comes in a metered dose pump. One pump actuation delivers 0.87 grams of gel which provides 0.52 mg of estradiol. 

Typical initial dose: apply 0.87 grams (one pump actuation) to clean, dry, and intact skin of the upper arm once a day. Your doctor may change your dose based on your response to the medication. 

Avoid applying the gel to the breast or in or around the vagina. Wash your hands with soap and water after applying the gel. Wait at least 2 hours before you let anyone touch the skin where you applied the gel.


Estradiol is the active ingredient in Elestrin. 


You should not use Elestrin (estradiol gel) if you have:

  • Undiagnosed unusual genital bleeding
  • Active breast cancer or a history of breast cancer
  • Estrogen-dependent neoplasia
  • An active deep vein thrombosis or pulmonary embolism or a history of these conditions
  • Had a previous anaphylactic reaction, swelling, or hypersensitive reaction with Elestrin
  • Liver problems or liver disease
  • Protein C, protein S, antithrombin deficiency, or other thrombophilic disorders



See full prescribing information for complete boxed warning.

Estrogen-Alone Therapy

  • There is an increased risk of endometrial cancer in a woman with a
    uterus who uses unopposed estrogens 
  • Do not use estrogen-alone therapy should for the prevention of
    cardiovascular disease or dementia 
  • The Women's Health Initiative (WHI) estrogen-alone substudy
    reported increased risks of stroke and deep vein thrombosis (DVT)
  • The WHI Memory Study (WHIMS) estrogen-alone ancillary study
    of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older

Estrogen Plus Progestin Therapy

  • Do not use estrogen plus progestin therapy for the prevention of
    cardiovascular disease or dementia 
  • The WHI estrogen plus progestin substudy reported increased risks
    of stroke, DVT, pulmonary embolism (PE), and myocardial
    infarction (MI) 
  • The WHI estrogen plus progestin study reported increased risks of
    invasive breast cancer 
  • The WHIMS estrogen plus progestin ancillary study of WHI
    reported an increased risk of probable dementia in postmenopausal women 65 years of age and older 
  • Discuss your medical history with your doctor, including your medical conditions, allergies, and medications.
  • Your risk for gallbladder disease may be increased with the use of Elestrin. 
  • Your calcium levels in your blood may increase with the use of Elestrin. 
  • Elestrin may cause vision problems, such as retinal vascular thrombosis. 
  • Tell your doctor if you have high cholesterol.
  • Tell your doctor if you have liver problems. 
  • Tell your doctor if you have thyroid problems.
  • Tell your doctor if you are pregnant or plan to become pregnant.
  • Tell your doctor if you are breastfeeding or plan to breastfeed.

Side Effects

Like with any medication, Elestrin can cause side effects. The most common include breast tenderness, spotting or vaginal bleeding, common cold, and upper respiratory tract infection. 

Seek emergency care immediately if you experience any of the following:

  • Heart attack: chest pain, cold sweats, pain in the left arm, trouble breathing
  • Stroke: Onset of weakness on one side of your body, headaches, difficulty breathing, slurred speech, blurry vision
  • Blood clots: pain, redness, or swelling in the legs, legs that are warm, breathing trouble, chest pain, cough
  • Breast lumps
  • Abnormal vaginal bleeding


  1. Elestrin Prescribing Information. Somerset, NJ: Meda Pharmaceuticals Inc.; 2020.
  2. Estradiol gel. GoodRx. Accessed January 30, 2022. 

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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