Ebglyss (Lebrikizumab)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Ebglyss (lebrikizumab-lbkz) is a humanized monoclonal antibody that targets interleukin-13 (IL-13), a cytokine involved in the inflammatory response associated with atopic dermatitis (AD). By inhibiting IL-13 signaling, Ebglyss reduces inflammation and helps improve skin lesions in patients with moderate-to-severe AD. It is indicated for use in adults and pediatric patients aged 12 years and older who weigh at least 40 kg and whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Ebglyss can be used with or without topical corticosteroids.

Fact Table

Formula

C6476H9994N1726O2036S46

License

EMA (2023), US FDA (2023)

Bioavailability

Subcutaneous: ~77%

Legal status

Prescription only

Chemical Name

Lebrikizumab

Elimination half-life

18–25 days

Dosage (Strength)

150 mg/mL prefilled syringe or autoinjector

Pregnancy

Use only if clearly needed – no adequate human data

Brands

Ebglyss

Protein binding

High (monoclonal antibody)

PubChem CID

121585681

MedlinePlus

a622058

ChEBI

Not listed

ATC code

D11AH07

DrugBank

DB12310

KEGG

D12348

Routes of administration

Subcutaneous injection

Directions

Ebglyss is administered via subcutaneous injection. The recommended dosing regimen is as follows:

  • Initial dose: 500 mg (two 250 mg injections) at Week 0 and Week 2.
  • Follow-up dosing: 250 mg every two weeks until Week 16 or later, when adequate clinical response is achieved.
  • Maintenance dose: 250 mg every four weeks.

Ebglyss is available as a 250 mg/2 mL solution in single-dose prefilled pens or syringes. Prior to initiating therapy, complete all age-appropriate vaccinations according to current immunization guidelines.

Ingredients

  • Active ingredient: lebrikizumab-lbkz.
  • Inactive ingredients: glacial acetic acid, histidine, polysorbate 20, sucrose, and water for injection.

Contraindications

Ebglyss is contraindicated in patients with known hypersensitivity to lebrikizumab or any of its excipients.

Cautions

  • Vaccinations: Avoid the use of live vaccines immediately prior to or during treatment with Ebglyss. Complete all age-appropriate vaccinations before initiating therapy.
  • Eye conditions: Monitor for new or worsening eye conditions, such as conjunctivitis or keratitis.
  • Infections: Be vigilant for signs of herpesvirus infections, including shingles.

Side Effects

Common side effects may include:

  • Injection site reactions (pain, itching, rash).
  • Eye and eyelid inflammation (redness, swelling, itching).
  • Conjunctivitis (pink eye).
  • Herpesvirus infections, including shingles.

Serious side effects may include:

  • Allergic reactions (hives, difficulty breathing, swelling of the face, lips, tongue, or throat).
  • Keratitis (inflammation of the cornea), presenting as eye redness, pain, or blurred vision.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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