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Duavee(Conjugated Estrogens / Bazedoxifene)

Known as Duavive in the UK

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
0.45mg/20mg
Pack Size
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Duavee is made up of conjugated estrogens and an estrogen agonist/antagonist, bazedoxifene. This combination medication is used to treat symptoms of menopause and prevent postmenopausal osteroporosis, or loss of bone mass that leads to fragile bones, in women who have a uterus.

Duavee comes in an oral tablet that contains 0.45 mg of conjugated estrogens and 20 mg of bazedoxifene.

Directions

Take Duavee as your doctor has prescribed. Any questions or concerns can be answered by your doctor or pharmacist.

It's recommended to take one Duavee tablet by mouth once daily, at the same time each day, with or without food. The tablet should be swallowed whole.

Ingredients

Conjugated estrogens and bazedoxifene, an estrogen agonist/antagonist, are the active ingredients in each Duavee tablet.

Calcium phosphate tribasic, hydroxypropyl cellulose, microcrystalline cellulose, powdered cellulose, hypromellose, lactose monohydrate, magnesium stearate, polyethylene glycol, sucrose, ascorbic acid, sucrose palmitic acid ester, hydroxyethylcellulose, titanium dioxide, red iron oxide, yellow iron oxide, black iron oxide, povidone, polydextrose, maltitol, poloxamer 188, propylene glycol, and isopropyl alcohol are the inactive ingredients.

Contraindications

Duavee should be avoided if you have any of the following conditions:

  • Abnormal, undiagnosed vaginal bleeding 
  • Active, suspected, or a history of breast cancer 
  • Active or suspected estrogen-dependent neoplasia 
  • Active or a history of blood clots in the veins
  • Active or a history of blood clots in the arteries
  • Allergy to estrogens, bazedoxifene, or any of Duavee's other ingredients
  • Liver disorders
  • Active protein C, protein S, or antithrombin deficiency or other thrombophilic disorders 
  • Pregnant

Cautions

Duavee contains FDA Boxed Warnings regarding the following:

  • Additional estrogens should be avoided in women who are taking Duavee 
  • Women who have a uterus and take unopposed estrogens are at an increased risk of endometrial cancer 
  • Estrogens should not be used to prevent cardiovascular disease or dementia 
  • The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) 
  • The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women who were at least 65 years old
  • Before you start taking Duavee, discuss the following with your doctor:
    • All the medications you take
    • Your allergies
    • Your health history and current medical problems
    • If you are pregnant or breastfeeding
  • Because Duavee contains estrogens, progestins and extra estrogens and estrogen-agonists/antagonists should be avoided during treatment with Duavee. 
  • The risk of serious cardiovascular problems, including stroke and blood clots in the legs, lungs, or retinal vessels of the eye, is increased with the use of Duavee.
  • The risk of endometrial cancer, breast cancer, and ovarian cancer is increased with estrogen use. The effect of Duavee on the risk of breast and ovarian cancers has not been determined. It is recommended that women receive timely and appropriate examinations and checkups.
  • The risk of gallbladder problems is increased with estrogen use.
  • A blood clot in the retinal vessels of the eye can be caused by estrogens. Seek emergency care immediately if you develop vision problems such as vision loss, bulging of the eyes, double vision, or migraine. Depending on the results of your eye examination, your doctor may choose to discontinue your treatment with Duavee.
  • Blood pressure may increase with estrogen use.
  • Triglyceride levels that can lead to pancreatitis may increase with estrogen use.
  • Liver problems may worsen in women with impaired liver function or a history of cholestatic jaundice and are taking Duavee. Duavee should be avoided in women with liver problems.
  • Hypothyroidism may worsen with estrogen use. Women who are taking Duavee and thyroid hormone replacement may require a dose increase in their thyroid hormone replacement. 
  • Fluid retention can occur with estrogen use. Caution should be used in women with heart problems. Duavee should be avoided in women with kidney problems.
  • The symptoms of angioedema (swelling beneath the skin) in women who have hereditary angioedema may worsen with estrogen use.
  • Conditions like asthma, diabetes, seizures, migraine, porphyria, lupus, or benign liver tumors may worsen with estrogen use. Women who have any of these conditions should use Duavee with caution.
  • Premenopausal women should not take Duavee.

Side Effects

Duavee can cause muscle spasms, nausea, diarrhea, indigestion, stomach pain, pain in the mouth, pain in the neck, and dizziness. However, these are not all the side effects that can occur with Duavee treatment.

Call your doctor if you have side effects that bother you or won't go away.

Looking for a competitive Duavee price? You can buy Duavee (conjugated estrogens/bazedoxifene) online and with a valid prescription from your doctor at Canada Drugs Direct.

Reference:

  1. Duavee (conjugated estrogens/bazedoxifene). Philadelphia, PA: Wyeth Pharmaceuticals LLC; 2022.


IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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