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Drizalma Sprinkle (Duloxetine)

Prescription medicineOnly Available By Prescription

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Drizalma Sprinkle (duloxetine delayed-release) is a serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD) in adults, generalized anxiety disorder (GAD) in adults and pediatric patients (7 to 17 years old), diabetic peripheral neuropathic pain (DPNP) in adults, and chronic musculoskeletal pain in adults.

Fact Table






32% to 80%

Legal status


Chemical Name


Elimination half-life

12 hours

Dosage (Strength)

20mg, 30mg, 40mg, 60mg


Consult Doctor


Drizalma Sprinkle

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth (tablets)


Drizalma Sprinkle is available in delayed-release capsules of 20 mg, 30 mg, 40 mg, and 60 mg strengths. Drizalma Sprinkle may be taken with or without food. Avoid crushing or chewing the capsule. The capsule may be swallowed whole or opened to be sprinkled over applesauce or given by nasogastric tube.

If you forget to take a dose, take it as soon as you remember. Do not take two doses at once.

Dosing for Drizalma Sprinkle


Starting Dose

Target Dose

Maximum Dose

40 mg/day to 60 mg/day

Acute treatment: 40 mg/day (20 mg twice daily) to 60 mg/day (60 mg once daily or 30 mg twice daily)

Maintenance treatment: 60 mg/day

120 mg/day


Starting Dose

Target Dose

Maximum Dose


60 mg/day

60 mg once daily

120 mg/day


30 mg/day

60 mg once daily

120 mg/day

Children and Adolescents (7 to 17 years of age)

30 mg/day

30 mg to 60 mg once daily

120 mg/day


Starting Dose

Target Dose

Maximum Dose

60 mg/day

60 mg once daily

60 mg/day

Chronic Musculoskeletal Pain

Starting Dose

Target Dose

Maximum Dose

30 mg/day

60 mg once daily

60 mg/day


The active ingredient in Drizalma Sprinkle capsules is duloxetine hydrochloride


You should not take monoamine oxidase inhibitors (MAOIs) for treating psychiatric problems with Drizalma Sprinkle or within 5 days of discontinuing Drizalma Sprinkle. 

You should not take Drizalma Sprinkle within 2 weeks of discontinuing an MAOI for the treatment of psychiatric problems. 

You should not begin treatment with Drizalma Sprinkle if you are being treated with linezolid or intravenous methylene blue.



See full prescribing information for complete boxed warning.

  • Increased risk of suicidal thinking and behavior in pediatric and young adult patients taking antidepressants 
  • Closely monitor all antidepressant-treated patients for clinical worsening and emergence of suicidal thoughts and behaviors
  • Discuss your allergies with your doctor.
  • Discuss all the medications you take with your doctor. These include prescription, over-the-counter, vitamins, and herbal supplements.
  • Let your doctor know if you have liver issues. Drizalma Sprinkle may cause liver failure that can be fatal. Contact your doctor immediately if you develop yellowing of your eyes or skin or any other symptoms of liver problems.
  • Let your doctor know if you drink alcohol or have chronic liver disease.
  • Let your doctor know if you have blood pressure problems. Drizalma Sprinkle may cause a sudden drop in your blood pressure when standing from sitting or lying down.
  • The risk for serotonin syndrome is increased with the use of Drizalma Sprinkle by itself or with concomitant use of Drizalma Sprinkle and other serotonergic medications (SSRI, SNRI, triptans). Stop taking Drizalma Sprinkle and seek medical attention immediately if you experience agitation, confusion, dilated pupils, diarrhea, headache, excessive sweating, shivering, rapid heart rate, restlessness, trouble sleeping, problems with your blood pressure problems, muscle twitches, or muscle rigidity. 
  • Your risk for bleeding may be increased while taking Drizalma Sprinkle, especially if you take NSAIDs, aspirin, warfarin, or other antiplatelets or anticoagulants. Contact your doctor immediately if you experience signs of bleeding such as bleeding from your gums, bleeding from your nose, or blood in your stool.
  • Severe skin reactions can occur with the use of Drizalma Sprinkle. Stop taking Drizalma Sprinkle and seek medical care immediately if you develop blisters, peeling rash, or mucosal erosions.
  • Do not suddenly stop taking Drizalma Sprinkle due to the risk of discontinuation syndrome. 
  • If you have bipolar disorder, use caution while taking Drizalma Sprinkle. 
  • Let your doctor know if you have glaucoma or other eye problems.
  • Let your doctor know if you have seizures.
  • Let your doctor know if you have blood pressure problems.
  • Drizalma Sprinkle can cause low sodium levels. Let your doctor know immediately if you have nausea, vomiting, headache, confusion, drowsiness, weakness, tiredness, muscle weakness, muscle spasms or cramps, restlessness, irritability, or seizures. 
  • Let your doctor know if you have diabetes.

Side Effects

Let your doctor know if you develop any side effects while taking Drizalma Sprinkle. The most common side effects include dry mouth, nausea, drowsiness, constipation, decreased appetite, and excessive sweating. 


  1. Drizalma Sprinkle Prescribing Information. Cranbury, NJ: Sun Pharmaceutical Industries, Inc.; 2019.
  2. Serotonin syndrome. Mayo Clinic. January 22, 2022. Accessed January 27, 2022.
  3. Hyponatremia. Mayo Clinic. May 23, 2020. Accessed January 27, 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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