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Divigel 0.1% (Estradiol)

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Divigel is a prescription menopause medication for treatment of menopausal hot flashes and night sweats along with treating vaginal symptoms related to menopause. This estrogen replacement therapy drug works by increasing the estrogen hormone to counter depleted levels of it that come with a woman entering menopause years. Applying the gel to your skin allows Estradiol to be absorbed through it and moved into the bloodstream to counter menopause symptoms effectively so that they are less problematic for women during this time of their lives.

You can buy Divigel online with a prescription, and your lowest Divigel cost will be when you order medication online from Canada Drugs Direct.


The recommended starting dose for Divigel is 0.25mg and the gel is applied 1x daily onto the skin over the skin of the upper thigh. Spread the gel in a thin layer over a 5 to 7” circular area and it should be allowed to dry completely before dressing or covering the area in any way. Apply gel at the same time every day.

Wash hands thoroughly after application


The active ingredient in Divigel is Estradiol


Medication is not to be applied to other areas, and your prescription will clearly specify the application site

Keep medication away from any open flame source as the gel is flammable

Avoiding eating grapefruit or drinking grapefruit juice while using Divigel to treat menopause is recommended due to potential negative reaction.

Inform your doctor of any history heart disease, stroke, pulmonary embolism or breast or endometrial cancer before beginning on Divigel

This medication may not be suitable for woman who have liver dysfunction or deep vein thrombosis

Partial or complete vision loss will mean women need additional doctor consultation before starting on Divigel for menopause

Medication should be stored at room temperature


Negative drug interactions are possible between Divigel and other Rx medications, including anastrozole / bosentan / carbamazepine / celecoxib / ceritinib / clozapine / cobicistat / dabrafenib / dehydroepiandrosterone / desiccated thyroid / elagolix / eslicarbazepine / exemestane / lamotrigine / lenalidomide / levothyroxine / melatonin / mifepristone / mitotane / modafinil / ospemifene / phenobarbital / phenytoin / pomalidomide / primidone / rifabutin / rifampin / ropinirole / somatropin / tacrolimus / thalidomide / theophylline / tizanidine

Inform your doctor of all medications you are currently taking before receiving a prescription and then going to buy Divigel online

Side Effects

Side effects from Divigel are not common, but some users may experience acne. breast pain or tenderness, fluid retention, headache, irritability, migraine headaches, nausea, skin irritation, stomach cramps and bloating, vomiting or weight gain. If Divigel side effects are seen it may be best to discontinue use and meet with your doctor again to discuss other menopause treatment medication options.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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