Only Available By Prescription
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| Strength | Pack Size | Qty | |
|---|---|---|---|
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Strength
0.05% Cream 1 Tube
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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Diprolene is a high-potency topical corticosteroid containing betamethasone dipropionate, indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, including psoriasis, eczema, seborrheic dermatitis, and lichen planus. Diprolene acts by suppressing the release of inflammatory mediators, reducing vasodilation, and decreasing collagen synthesis. It is available in cream, ointment, gel, and lotion formulations, with augmented formulations designed to enhance skin penetration and increase efficacy in resistant dermatoses.
| Fact Table | |
| Formula | C28H37FO7 |
| License | US FDA; EMA |
| Bioavailability | <6% (topical, intact skin) |
| Legal status | Prescription only |
| Chemical Name | Betamethasone 17,21-dipropionate |
| Elimination half-life | ~5–6 hours (systemic) |
| Dosage (Strength) | 0.05% topical cream, ointment, gel, lotion, or augmented foam |
| Pregnancy | Category C – use only if clearly needed |
| Brands | Diprolene, Diprolene AF, generic betamethasone dipropionate |
| Protein binding | >60% |
| PubChem CID | 22855365 |
| MedlinePlus | a682799 |
| ChEBI | CHEBI:31208 |
| ATC code | D07AC01 |
| DrugBank | DB00443 |
| KEGG | D00972 |
| Routes of administration | Topical |
Apply a thin layer of Diprolene to the affected area once or twice daily, depending on the severity and the formulation used.
Each gram of Diprolene contains:
Inactive ingredients vary by formulation and may include:
Note: The augmented cream and ointment enhance penetration through the stratum corneum.
Diprolene is contraindicated in patients with:
Prolonged use, especially under occlusion or on large surface areas, can lead to systemic corticosteroid absorption, resulting in adrenal suppression, Cushing’s syndrome, hyperglycemia, and growth suppression in children. Avoid use on broken or atrophic skin. Use with caution in patients with diabetes mellitus or immunosuppression. Regularly assess for local side effects, including skin thinning, telangiectasia, and striae. Discontinue if irritation or infection develops. Use during pregnancy only if clearly needed and avoid prolonged use during breastfeeding.
Common and potential side effects include:
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