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Differin OTC (Adapalene)

Also Known as Adaferin


Top brand choice

Strength Pack Size Qty
Gel 0.10%
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Differin is a prescription acme medication that is applied topically on the skin to reduce the severity of acne breakouts and promote better skin healing from acne. It is prescribed for people who get inferior results from OTC acne treatment products and need something that is more effective for treating severe acne. This medication is part of the retinoid class of drugs that promote changes to the skin’s cells and also promote less swelling and inflammation. This medication is best used along with a good skin hygiene and cleaning regimen that limits the amount of sebum (oil) and contaminants present on the skin.

You can buy Differin gel with a doctor’s prescription at your local pharmacy, and your best price on it will be when you order medication online from Canada Drugs Direct.


Wash hands before applying medicated acne lotion. Use your fingertips to apply a small amount of the medication in a thin layer over acne affected skin. Allow to be absorbed fully before covering any affected areas of skin that are not on your face. Repeat daily.

Do not apply to areas of skin that are cut, scraped, sunburnt, or have eczema. This medication should not be used in conjunction with medicated creams for eczema applied to the same area.

It may take up to 12 weeks to start seeing results from the use of Differin moisturizer. Differin gel before and after evaluations should not be made any time within the first 8 weeks of treatment with this medicated acne solution.


The active ingredient in Differin gel is Adapalene.


Differin gel may not be suitable for people who have allergies to Vitamin-A related drugs.

Differin gel can increases sun sensitivity for skin, so you should avoid prolonged exposure to sun on unprotected skin while using this medication. It is also best to not undergo electrolysis, waxing, or use chemical depilatories on treated skin while using the medication.

Use Differin with caution if you have recently used skin products with sulfur, resorcinol, or salicylic acid. It may best to wait before beginning on this medication and this is something to discuss with a doctor.


There is the possibility of drug interaction risks between Differin moisturizer and other skincare products. These include alpha hydroxy acids, glycolic acid products, hair perming solutions, alcohol or lime/menthol-containing products like astringents, toners, and shaving lotions, medicated or abrasive soaps and cleansers, and soaps and cosmetics with a strong drying effect. Tell your doctor of any of these you may be using before receiving a prescription and proceeding to buy Differin gel.

Side Effects

Side effects from using Differin medicated gel for acne are uncommon, but some users may experience skin redness, dryness, itching, scaling, mild curing, or worsening acne. If these side effects are experienced you should stop using this medicated acne gel and meet with your doctor again to discuss other severe acne treatment options.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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