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Depo-Medrol (Methylprednisolone)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
40mg/ml 1ml
Pack Size

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Depo-Medrol (Methylprednisolone) is a synthetic glucocorticoid medication mainly prescribed for its anti-inflammatory and immunosuppressive effects. It works by preventing the release of substances in the body that cause inflammation. This medication is used to treat a wide variety of medical conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, lupus, skin conditions, kidney problems, and flare-ups of multiple sclerosis.

Fact Table




US FDA, US DailyMed



Legal status


Chemical Name


Elimination half-life

1.8–2.6 hours

Dosage (Strength)

40mg / ml 1ml


Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration



Ensure you follow the prescribed dosage given by your healthcare provider, which typically starts at 4 to 120 mg. The standard dosage and administration method may vary depending on the condition being treated and individual factors such as age, weight, and medical history. Typically, Depo-Medrol is administered through an injection, either into a muscle, joint, or directly into a problematic area.

The healthcare professional providing the injection will determine the most appropriate site for injection based on your specific treatment needs. A medical professional should administer Depo-Medrol injections. Always follow their guidance and instructions for the safe and effective use of Depo-Medrol.


The active ingredient in Depo-Medrol is Methylprednisolone acetate.


Avoid using Depo-Medrol if any of the following apply:

  • Allergy to Methylprednisolone or any ingredients in the medication
  • History of blood disorder called idiopathic thrombocytopenic purpura
  • Conditions that require intrathecal administration
  • Use in premature infants due to the formulation containing benzyl alcohol
  • Systemic fungal infections


  • Before using Depo-Medrol, inform your doctor about the following:
    • Any medications you take, especially anticoagulants, diabetic medications, and any medication that interacts with corticosteroids
    • Any medical conditions you have, such as diabetes, liver disease, kidney problems, or heart issues
    • If you are pregnant or planning to become pregnant, as Depo-Medrol may harm your unborn baby
    • If you are breastfeeding or planning to breastfeed, since the drug can pass into breast milk and potentially harm your baby
    • If you have had any recent surgeries or plan to have surgery with general anesthesia
  • Depo-Medrol may cause low potassium levels, which may cause leg cramps, constipation, irregular heartbeats, or muscle weakness.
  • This medication may have a possible impact on growth in children. Inform your doctor if you notice your child isn't growing at a normal rate while using Depo-Medrol.
  • This medication may carry a risk of serious neurological events following epidural administration, such as spinal cord infarction, paraplegia, or stroke.
  • When using multi dose vials, take special care to prevent contamination. A povidone-iodine solution is recommended for cleaning the vial top.
  • This steroid formulation is sensitive to heat. Do not autoclave the vial.
  • Use the lowest possible dose to control your condition. If a reduction in dosage is possible, it should be done gradually.
  • The metabolic clearance of corticosteroids varies with thyroid status. Inform your healthcare provider if you have any thyroid problems.
  • Use with caution if you have gastrointestinal issues like peptic ulcers, diverticulitis, or ulcerative colitis, as corticosteroids may increase the risk of perforation.
  • High doses may cause acute myopathy or psychological changes, ranging from mood swings to severe depression and psychosis.
  • If treatment extends beyond 6 weeks, intraocular pressure should be monitored. Use cautiously if you have ocular herpes simplex.
  • Do not discontinue abruptly or without medical supervision. If you develop a fever or other signs of infection, seek medical advice immediately. Avoid exposure to chickenpox or measles.

Side Effects

Depo-Medrol (Methylprednisolone) may cause side effects. Common side effects can include weight gain, slow wound healing, headache, muscle pain or weakness, thinning skin, and increased sweating. Some people might also experience other effects, such as aggression, agitation, blurred vision, mood changes, and numbness or tingling in the arms or legs.

More serious side effects of Depo-Medrol requiring immediate medical attention include severe heart problems, pancreatitis, esophagitis, seizures, vision problems, and allergic reactions. Consult a healthcare provider for possible side effects associated with Depo-Medrol, as this is not a complete list. If any concerning side effects occur, consult your doctor or healthcare provider.


  1. Depo-Medrol (Methylprednisolone) Prescribing Information. New York, NY: Pfizer; 2021
  2. Depo-Medrol (Methylprednisolone) Drug Label Information. Parsippany, NW: Zoetis, Inc; 2021

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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