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Deplin (Levomefolate Calcium)

Prescription medicineOnly Available By Prescription

Top Generic choice

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Deplin is a medical food product that should be used under the supervision of a physician or other healthcare professional. It is available for supplementation when folate cannot be obtained through normal modification to the diet.

Deplin is indicated to treat hyperhomocysteinemia in schizophrenia and Major Depressive Disorder (MDD). Deplin helps to correct nutritional deficiencies that arise within these conditions.

These conditions are sometimes known to also have nutrient deficiencies that can be treated with a medical food product like Deplin.

Deplin is available in Deplin 7.5 mg capsules and Deplin 15 mg capsules.

Fact Table







Legal status


Chemical Name

Levomefolate Calcium

Elimination half-life

3 hour

Dosage (Strength)

7.5mg, 15mg


Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration



Take Deplin precisely as prescribed by your healthcare provider. Deplin should not be used without the supervision of a healthcare professional.

The usual dosage is 7.5-15 mg by mouth once daily. Take Deplin with or without food. 


Deplin generic contains the active ingredient L-methylfolate. L-methylfolate is an active form of folic acid that is readily absorbed in the brain.


Tell your doctor and pharmacist about all of the medication and supplements you are taking before starting treatment with Deplin. Common drug-drug interactions may include:

  • Alcohol
  • Capecitabine
  • Carbamazepine
  • Cholestyramine
  • Cigarettes
  • Colestipol
  • Cycloserine
  • Ibuprofen
  • Indomethacin
  • Isotretinoin
  • Lamotrigine
  • Methotrexate
  • Methylprednisolone
  • Naproxen
  • Oral contraceptives
  • Pancreatic enzymes
  • Pentamidine
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Pyrimethamine
  • Sulfasalazine
  • Sulindac
  • Triamterene
  • Trimethoprim
  • Valproic acid

Use caution if you are taking any of the above medications.


Deplin capsules contain milk and soy and should not be used if you are allergic to these components.

Do not use Deplin if you are allergic to any of the inactive ingredients. 

Side Effects

Allergic reactions (hypersensitivity) have been reported with the use of Deplin, but there are no other known Deplin side effects.


Deplin [package insert]. Covington, LA: Pamlab; 2009.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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