Dapsone

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
25mg
Pack Size
Qty
Strength
100mg
Pack Size
Qty

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Dapsone is an antibiotic that doctors prescribe for treating leprosy (Hansen's disease) and dermatitis herpetiformis, which is a form of itchy skin rash. Classified as a sulfone, this medication works by interfering with the bacteria's cell processes, slowing their growth and spread. It may also serve purposes beyond these specific conditions under a healthcare provider's direction.

Fact Table

Formula

C12H12N2O2S

License

US FDA

Bioavailability

70-90%

Legal status

Rx-only (Prescription only)

Chemical Name

4,4'-Diaminodiphenyl sulfone

Elimination half-life

20-30 hours

Dosage (Strength)

25 mg, 50 mg, 100 mg tablets; 5% gel

Pregnancy

Consult a doctor (Risk varies depending on the condition)

Brands

Aczone, Avlosulfon, Dapsone

Protein binding

70-90%

PubChem CID

2955

MedlinePlus

a682128

ChEBI

4325

ATC code

J04BA02

DrugBank

DB00250

KEGG

D00350

Routes of administration

Oral, Topical

Directions

Dapsone is typically prescribed in either a topical gel for acne treatment or as an oral medication for various skin conditions and infections. For oral administration, patients usually take Dapsone once a day or as directed by their healthcare provider. The standard oral dosage can vary, but typically it's between 50 to 100 milligrams (mg) daily for adults. While taking this drug, it's important to follow a healthcare provider's instructions closely and attend regular check-ups to monitor the treatment's progress.

Ingredients

Dapsone contains an active ingredient by the same name, chemically known as 4,4'-diaminodiphenylsulfone (DDS).

Contraindications

Avoid taking or using Dapsone if you have a known hypersensitivity to Dapsone or its derivatives.

Cautions

  • Before beginning treatment with Dapsone, make sure to disclose the following to your healthcare provider:
    • Any existing health conditions
    • Known allergies
    • A complete list of medications you are currently using
    • Your status regarding pregnancy or breastfeeding
  • Use Dapsone cautiously if you have liver or kidney issues, or a deficiency in glucose-6-phosphate dehydrogenase (G6PD). These conditions can make side effects more likely.
  • Manage severe anemia before starting Dapsone. Regular blood checks are important because Dapsone can cause hemolytic anemia, particularly if you're prone to this condition.
  • Watch out for symptoms like sore throat, fever, unusual bruising or bleeding, or yellowing of the skin (jaundice). These symptoms may mean you need to stop taking Dapsone.
  • If you have heart or lung disease, be aware that the breakdown of red blood cells caused by Dapsone could worsen your condition.
  • Dapsone can lead to serious skin reactions such as rashes and blistering. Stop taking Dapsone and seek immediate medical help if you notice any severe skin reactions.
  • Monitor your liver function before and during your treatment with Dapsone, especially if you experience symptoms like yellowing of the skin or eyes, as these could indicate liver issues.
  • Be mindful of potential interactions with other medications, particularly those that also affect your blood cells. Increased monitoring may be necessary if you're taking other medications like pyrimethamine alongside Dapsone.

Side Effects

Dapsone is generally well-tolerated at doses up to 100 mg daily, with common side effects including nausea, headaches, dizziness, and insomnia. Skin reactions such as rashes can also occur. Those with certain enzyme deficiencies might experience more severe reactions like hemolysis or methemoglobinemia at lower doses. It's important to monitor for these effects, especially when daily intake exceeds 50 mg.

Serious side effects may include the "Dapsone syndrome," a potentially fatal hypersensitivity reaction characterized by rash, fever, and other severe symptoms, which can develop within the first six weeks of therapy. Other severe risks include agranulocytosis, peripheral neuropathy, and rare kidney issues. If any unusual or serious effects develop, consult a healthcare provider promptly.

References

  1. Dapsone Product Monograph. Warriewood, AU: Link Medical Products Pty Ltd; 2024.
  2. Dapsone Drug Label Information. Princeton, NJ: Jacobus Pharmaceutical Company, Inc.; 2022.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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