Only Available By Prescription
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| Strength | Pack Size | Qty | |
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Strength
25mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Dantrium (dantrolene sodium) is a skeletal muscle relaxant indicated for the treatment and prevention of malignant hyperthermia (MH), as well as for the management of chronic spasticity associated with conditions such as cerebral palsy, multiple sclerosis, stroke, and spinal cord injury. It acts peripherally at the level of the skeletal muscle fiber by interfering with calcium release from the sarcoplasmic reticulum, reducing muscle contractions. In the context of MH, Dantrium is a life-saving antidote, reversing the hypermetabolic crisis caused by certain anesthetics or depolarizing muscle relaxants.
| Fact Table | |
| Formula | C14H10N4O5 |
| License | US FDA (1974); EMA |
| Bioavailability | ~70% (oral) |
| Legal status | Prescription only |
| Chemical Name | 1-[[5-(4-nitrophenyl)furfurylidene]amino]hydantoin |
| Elimination half-life | ~8.7 hours (oral); 4–11 hours (IV) |
| Dosage (Strength) | 25 mg, 50 mg, 100 mg oral capsules; 20 mg powder for IV reconstitution |
| Pregnancy | Category C – caution advised |
| Brands | Dantrium, Revonto, Ryanodex (IV formulations) |
| Protein binding | ~75% |
| PubChem CID | 54682931 |
| MedlinePlus | a682006 |
| ChEBI | CHEBI:4325 |
| ATC code | M03CA01 |
| DrugBank | DB01219 |
| KEGG | D00298 |
| Routes of administration | Oral, Intravenous (IV) |
Dantrium is available in oral capsule and intravenous formulation:
IV formulations must be reconstituted carefully and administered through a large vein to minimize phlebitis. Transition to oral dosing post-crisis may be considered for maintenance.
Oral capsules (25 mg, 50 mg, or 100 mg) contain:
Inactive ingredients may include lactose, magnesium stearate, starch, and capsule components.
IV formulation (for injection):
Dantrium is contraindicated in:
Dantrolene carries a boxed warning for potential hepatotoxicity, which may be fatal. Risk is higher with long-term use and doses >400 mg/day. Regular liver function tests (AST, ALT, bilirubin) should be performed before and during therapy. Use with caution in patients with cardiac or pulmonary disease, as it may cause respiratory or cardiovascular compromise. Dantrolene may cause photosensitivity—advise sun protection. It can also potentiate the effects of CNS depressants and muscle relaxants. In MH crises, monitor for electrolyte imbalances, acidosis, and supportive care needs.
Common and potential side effects include:
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If you have any questions at all, or would like to place an order, you are encouraged to contact us by toll-free
phone 1-888-904-8467 or email info@canadadrugsdirect.com.
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