Cyclomen (Danazol)

Description

Cyclomen (Danazol) is a synthetic steroid derived from ethisterone and is classified as a pituitary gonadotropin inhibitor. It is used to treat endometriosis, a condition causing infertility and pelvic pain, by managing tissue growth outside the uterus. In addition, it may help ease pain and discomfort resulting from benign fibrocystic breast disease and prevent hereditary angioedema attacks. The drug works by suppressing the production of certain hormones in the body, such as gonadotropins.

Directions

Before using Cyclomen, consult your doctor or healthcare provider to determine the appropriate dosage based on your specific condition and needs. Cyclomen is usually taken orally multiple times daily for a maximum of three to six months. Follow the directions provided on the prescription.

Ingredients

The primary ingredient in Cyclomen is Danazol. Cyclomen capsules may also contain inactive ingredients, including cornstarch, titanium dioxide, magnesium stearate, gelatin, lactose, talc, red iron oxide, and yellow iron oxide.

Contraindications

Avoid taking or using Cyclomen if any of the following apply:

• Unexplained vaginal bleeding
• A blood condition known as porphyria
• Cancer of the breast, cervix/uterus, or vaginal area
• Pregnancy or nursing
• Androgen-dependent tumors
• Allergies to Danazol or any ingredient in the medication
• Concurrent use of simvastatin
• Serious liver issues
• Advanced kidney disease
• Severe heart problems
• Previous incidents of stroke or blood clots

Cautions

• Before starting treatment with Cyclomen, consider discussing the following with your doctor:
• All medications you are taking, including prescription, over-the-counter, and herbal supplements, as they may interact with Cyclomen.
• Medical history and any existing health conditions, as these might require dosage adjustments or additional monitoring.
• If you're pregnant or planning to become pregnant
• If you are breastfeeding or plan to

• Cyclomen may alter plasma levels of specific proteins like prealbumin and C1-esterase inhibitor; however, the clinical effects are unclear.
• Be aware that Cyclomen can cause temporary changes in cholesterol levels, which may have heart-related risks.
• Regular liver and blood tests are recommended during treatment with Cyclomen.
• After treatment for fibrocystic breast disease, using non-hormonal contraception may be recommended until the menstrual cycle is regular again.
• Cyclomen may increase the effects of blood thinners like Coumadin, which might require closer monitoring and dosage changes.
• Taking Cyclomen alongside certain medications like carbamazepine, phenytoin, and phenobarbital may require dosage adjustments.
• Concurrent use of Cyclomen with cyclosporin or tacrolimus can increase plasma concentrations of these drugs, raising the risk for kidney problems.
• Cyclomen has the potential to interfere with insulin effectiveness. If you're diabetic, adjustments to your insulin dosage may be needed.
• Cyclomen may reduce the effectiveness of blood pressure medications and could interact with other hormone treatments.
• Monitoring is advised for changes in laboratory values like CPK, glucose tolerance, and other plasma proteins during Cyclomen treatment.

Side Effects

Cyclomen may cause various side effects. Common Danazol side effects include acne, facial puffiness, a mild growth of body hair, and a decrease in breast size. Other common effects include weight gain, a deeper voice, and oilier skin or hair.

The medication may also cause side effects linked to reduced estrogen levels, such as hot flashes, sweating, or vaginal issues like itching, dryness, or minor bleeding. Some people have mentioned feeling emotionally shaky or more nervous while on this drug.

If you notice severe side effects, seek medical help right away. Ongoing headaches or stomach pain could be a sign of problems with the nervous system or digestive tract, such as pancreatitis. In rare cases, individuals taking Danazol may experience pneumonia or severe skin irritation. Another concerning risk is liver damage, which could cause symptoms like a loss of appetite, skin or eye yellowing, and unusually dark pee. If any serious side effects occur, reach out to a healthcare professional immediately.

References:

1. Cyclomen (Danazol) Product Monograph. Laval, Quebec: Sanofi-Aventis; 2017.

Cyclomen (Danazol) Drug Label Information. Parsippany, NJ: Teva Pharmaceuticals; 2022

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....