Cyclomen (Danazol)

Prescription medicineOnly Available By Prescription
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50mg
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100mg
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Strength
200mg
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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Cyclomen (Danazol) is a synthetic steroid derived from ethisterone and is classified as a pituitary gonadotropin inhibitor. It is used to treat endometriosis, a condition causing infertility and pelvic pain, by managing tissue growth outside the uterus. In addition, it may help ease pain and discomfort resulting from benign fibrocystic breast disease and prevent hereditary angioedema attacks. The drug works by suppressing the production of certain hormones in the body, such as gonadotropins.


Fact Table

Formula

C22H27NO2

License

US FDA

Bioavailability

Saturable with dosage, higher with food intake

Legal status

Rx-only

Chemical Name

Danazol

Elimination half-life

Acute: 3–10 hours, Chronic: 24–26 hours

Dosage (Strength)

50mg, 100mg, 200mg

Pregnancy

Danazol must not be taken

Brands

Cyclomen

Protein binding

Not Available

PubChem CID

28417

MedlinePlus

a682599

ChEBI

4315

ATC code

G03XA01

DrugBank

DB01406

KEGG

D00289

Routes of administration

By mouth

Directions

Before using Cyclomen, consult your doctor or healthcare provider to determine the appropriate dosage based on your specific condition and needs. Cyclomen is usually taken orally multiple times daily for a maximum of three to six months. Follow the directions provided on the prescription.

Ingredients

The primary ingredient in Cyclomen is Danazol. Cyclomen capsules may also contain inactive ingredients, including cornstarch, titanium dioxide, magnesium stearate, gelatin, lactose, talc, red iron oxide, and yellow iron oxide.

Contraindications

Avoid taking or using Cyclomen if any of the following apply:

  • Unexplained vaginal bleeding
  • A blood condition known as porphyria
  • Cancer of the breast, cervix/uterus, or vaginal area
  • Pregnancy or nursing
  • Androgen-dependent tumors
  • Allergies to Danazol or any ingredient in the medication
  • Concurrent use of simvastatin
  • Serious liver issues
  • Advanced kidney disease
  • Severe heart problems
  • Previous incidents of stroke or blood clots

Cautions

  • Before starting treatment with Cyclomen, consider discussing the following with your doctor:
    • All medications you are taking, including prescription, over-the-counter, and herbal supplements, as they may interact with Cyclomen.
    • Medical history and any existing health conditions, as these might require dosage adjustments or additional monitoring.
    • If you're pregnant or planning to become pregnant
    • If you are breastfeeding or plan to
  • Cyclomen may alter plasma levels of specific proteins like prealbumin and C1-esterase inhibitor; however, the clinical effects are unclear.
  • Be aware that Cyclomen can cause temporary changes in cholesterol levels, which may have heart-related risks.
  • Regular liver and blood tests are recommended during treatment with Cyclomen.
  • After treatment for fibrocystic breast disease, using non-hormonal contraception may be recommended until the menstrual cycle is regular again.
  • Cyclomen may increase the effects of blood thinners like Coumadin, which might require closer monitoring and dosage changes.
  • Taking Cyclomen alongside certain medications like carbamazepine, phenytoin, and phenobarbital may require dosage adjustments.
  • Concurrent use of Cyclomen with cyclosporin or tacrolimus can increase plasma concentrations of these drugs, raising the risk for kidney problems.
  • Cyclomen has the potential to interfere with insulin effectiveness. If you're diabetic, adjustments to your insulin dosage may be needed.
  • Cyclomen may reduce the effectiveness of blood pressure medications and could interact with other hormone treatments.
  • Monitoring is advised for changes in laboratory values like CPK, glucose tolerance, and other plasma proteins during Cyclomen treatment.

Side Effects

Cyclomen may cause various side effects. Common Danazol side effects include acne, facial puffiness, a mild growth of body hair, and a decrease in breast size. Other common effects include weight gain, a deeper voice, and oilier skin or hair.

The medication may also cause side effects linked to reduced estrogen levels, such as hot flashes, sweating, or vaginal issues like itching, dryness, or minor bleeding. Some people have mentioned feeling emotionally shaky or more nervous while on this drug.

If you notice severe side effects, seek medical help right away. Ongoing headaches or stomach pain could be a sign of problems with the nervous system or digestive tract, such as pancreatitis. In rare cases, individuals taking Danazol may experience pneumonia or severe skin irritation. Another concerning risk is liver damage, which could cause symptoms like a loss of appetite, skin or eye yellowing, and unusually dark pee. If any serious side effects occur, reach out to a healthcare professional immediately.

References:

  1. Cyclomen (Danazol) Product Monograph. Laval, Quebec: Sanofi-Aventis; 2017.

Cyclomen (Danazol) Drug Label Information. Parsippany, NJ: Teva Pharmaceuticals; 2022




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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