Cuprimine (Penicillamine)

Also Known as Distamine

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Cuprimine is a prescription rheumatoid arthritis medication that counters the inflammation response that causes arthritis pain, but it can also be as a medication for treating Wilson’s disease. It’s a disease that elevates copper levels in the body too high and results in organ damage. It can also be used to treat cystinuria, a condition which leads to painful kidney stones. Cuprimine works as an arthritis treatment drug by reducing the inflammatory response, and for Wilson’s disease it could bind to copper and then excrete it from the body. Kidney stones are countered by reducing cystine in the urine.


Follow instructions as indicated in your prescription. The standard starting dose is one Cuprimine tablet taken on an empty stomach and 1 to 2 hours before or after a meal. It is best to take this medication around the same time every day.

It may be necessary to take this medication along with vitamin B6 (Pyridoxine) and iron if advised to do so by your doctor. If you do need to take iron, then you should take it at least 2 hours before or after taking your daily Cuprimine dose.


The active ingredient in Cuprimine is Penicillamine.


Tell your doctor if you have any history of aplastic anemia, agranulocytosis, kidney disease, blood or bone marrow disorders like thrombocytopenia before beginning on Cuprimine.

Use of the is medication may not be suitable for women who are pregnant or breast feeding. Do so only if approved by your doctor.


There is the possibility of drug interaction risks between Cuprimine and other Rx medications, including digoxin, gold salts like auranofin, malaria treatment drugs like chloroquine, phenylbutazone, bone marrow function drugs like azathioprine, and cancer chemotherapy drugs like trimethoprim and sulfamethoxazole.

It is best to tell your doctor of all medications you are currently taking before receiving a prescription and proceeding to buy Cuprimine.

Side Effects

Cuprimine side effects are uncommon, but some people may experience stomach or abdominal pain, diarrhea, persistent sore throat, or decreased sense of taste. If Cuprimine side effects are experienced you should discontinue use and speak to your doctor again regarding rheumatoid arthritis treatment options.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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