Cortrophin Gel

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Cortrophin Gel (repository corticotropin injection) is a purified sterile preparation of the adrenocorticotropic hormone (ACTH) in gelatin, indicated for the treatment of several inflammatory and autoimmune conditions. It stimulates the adrenal cortex to secrete endogenous corticosteroids and is used in disorders responsive to corticosteroids, including multiple sclerosis (MS) exacerbations, rheumatoid arthritis, systemic lupus erythematosus (SLE), sarcoidosis, and certain nephrotic syndromes. Cortrophin Gel is a long-acting formulation administered subcutaneously or intramuscularly, offering an alternative for patients who are unresponsive to or unable to tolerate oral corticosteroids.

Fact Table

Formula

C207H308N56O58S

License

US FDA (re-approved 2021)

Bioavailability

Not precisely established (IM/subQ depot)

Legal status

Prescription only

Chemical Name

Repository corticotropin injection (ACTH analog)

Elimination half-life

~15 hours (variable)

Dosage (Strength)

80 U/mL in 5 mL multi-dose vial

Pregnancy

Use only if clearly needed

Brands

Cortrophin Gel

Protein binding

Unknown (peptide hormone)

PubChem CID

16129669

MedlinePlus

a682189

ChEBI

80288

ATC code

H01AA01

DrugBank

DB00109

KEGG

D00093

Routes of administration

Intramuscular (IM), Subcutaneous (SubQ)

Directions

Cortrophin Gel is administered via intramuscular or subcutaneous injection. Dosage varies by indication and patient response, typically ranging from 40 to 80 units daily or every other day. For multiple sclerosis exacerbations, the recommended dose is 80–120 units daily for 2 to 3 weeks. In nephrotic syndrome or rheumatologic conditions, dosing and duration should be individualized. The product must be shaken well before use and injected using aseptic technique. Therapy should be tapered gradually after a treatment course to avoid adrenal insufficiency.

Ingredients

Each mL of Cortrophin Gel contains:

  • Repository corticotropin injection 80 USP units
  • Gelatin, phenol (as preservative), sodium chloride, sodium phosphate (monobasic and dibasic), and water for injection

Contraindications

Cortrophin Gel is contraindicated in patients with:

  • Systemic fungal infections
  • Ocular herpes simplex (due to risk of corneal perforation)
  • Hypersensitivity to ACTH or any component of the formulation
  • Primary adrenocortical insufficiency or adrenogenital syndrome
  • Recent surgery or serious infections, unless benefits outweigh risks

Cautions

Use caution in patients with diabetes mellitus, congestive heart failure, peptic ulcer disease, osteoporosis, or psychiatric disorders, as ACTH-induced steroidogenesis may exacerbate these conditions. Long-term use may lead to adrenal suppression, increased susceptibility to infections, Cushingoid features, and growth retardation in pediatric patients. Monitor electrolyte balance, blood pressure, blood glucose, and signs of infection regularly during treatment.

Side Effects

Common and potential side effects include:

  • Fluid retention and edema
  • Hypertension
  • Mood changes or insomnia
  • Increased blood glucose
  • Gastrointestinal upset
  • Muscle weakness or atrophy
  • Weight gain
  • Osteoporosis with prolonged use
  • Rare: adrenal suppression, allergic reactions, seizures (particularly in infants)

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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