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Contrave (Bupropion/Naltrexone)

Also Known as Mysimba

Prescription medicineOnly Available By Prescription
Sezzle

Top brand choice

Strength Pack Size Qty
Strength
8mg/90mg
Pack Size
Qty

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Contrave is a combination of two medications: naltrexone, an opioid antagonist, and bupropion, an antidepressant. It is a weight-loss medication that is used with diet and exercise in obese adults or overweight adults who have a weight-related comorbidity such as diabetes, high blood pressure or high cholesterol.

Contrave comes in an extended-release oral tablet containing 8 mg of naltrexone hydrochloride (HCl) and 90 mg of bupropion HCl.

Fact Table

Formula

C9H13NO3

License

EU EMA, US FDA

Bioavailability

Unknown

Legal status

RX Only

Chemical Name

Naltrexone/Bupropion

Elimination half-life

5 hours

Dosage (Strength)

8mg or 90mg (112 tablets)

Pregnancy

Consult a doctor

Brands

Contrave

Protein binding

Naltrexone 21%, Bupropion 84%

PubChem CID

11556075

MedlinePlus

a619020

ChEBI

Unknown

ATC code

A08AA62

DrugBank

DB00704

KEGG

D10751

Routes of administration

By mouth

Directions

Take Contrave as directed by your doctor. Your doctor may increase your dose every week for four weeks, up to a maximum of 2 tablets by mouth twice daily.

Tell your doctor or pharmacist if you have any questions or concerns.

Ingredients

8 mg of naltrexone hydrochloride (HCl) and 90 mg of bupropion HCl is contained in each extended-release tablet. Microcrystalline cellulose, hydroxypropyl cellulose, lactose anhydrous, L-cysteine hydrochloride, crospovidone, magnesium stearate, hypromellose, edetate disodium, lactose monohydrate, colloidal silicon dioxide, Opadry II Blue, and FD and C Blue #2 aluminum lake are the inactive ingredients included.

Contraindications

Contrave should not be given to patients who:

  • Have uncontrolled high blood pressure
  • Have seizure disorders
  • Have anorexia nervosa or bulimia
  • Are undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic medications
  • Are taking other medications that contain bupropion
  • Are taking opioids chronically
  • Are taking monoamine oxidase inhibitors (MAOIs)
  • Have an allergy to naltrexone, bupropion, or any of the other ingredients in Contrave

Cautions

  • Contrave has a FDA Boxed Warning regarding an increased risk of suicidal thoughts or behavior; therefore, patients should be monitored for signs or symptoms of suicidal thoughts or behaviors while they are taking Contrave.
  • Before beginning treatment with Contrave, inform your doctor of:
    • All the medications you take
    • Your allergies
    • Your medical history and current health problems
    • Your pregnancy or breastfeeding status
  • Patients who take Contrave and are quitting smoking may experience neuropsychiatric adverse events such as mood changes, psychosis, hallucinations, paranoia, agitation, and anxiety. Patients should tell their doctor immediately if they experience any of these effects.
  • Patients who adhere to the recommended dosing schedule and avoid eating a high-fat meal when taking Contrave may be at a lower risk of seizures.
  • Contrave may cause an increase in heart rate and blood pressure.
  • Contrave may cause damage to the liver.
  • Contrave may cause glaucoma.
  • Patients who are experiencing weight loss with Contrave and are taking antidiabetic medications may develop low blood sugar.

Side Effects

Nausea, constipation, headache, vomiting, dizziness, sleep problems, dry mouth, and diarrhea are the most common Contrave side effects; however, these are not the only side effects that can occur. Call your doctor right away if you have side effects that bother you or won't go away.

Reference:

Contrave. Brentwood, TN: Currax™ Pharmaceuticals, LLC; 2021.




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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