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Complera (Emtricitabine / Rilpivirine / Tenofovir Disoproxil Fumarate)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Complera is a three-drug combination containing two nucleoside analog HIV-1 reverse transcriptase inhibitors, emtricitabine and tenofovir disoproxil fumarate, and one non-nucleoside reverse transcriptase inhibitor, rilpivirine. This three-in-one medication is used to treat HIV-1 infection in patients who weigh at least 35 kg. 

Complera may not be right for everyone. Talk to your doctor about which treatment option may be best for you.

Complera comes in an oral tablet containing 200 mg of emtricitabine, 25 mg of rilpivirine, and 300 mg of tenofovir disoproxil fumarate.


The instructions that come with your Complera prescription should be carefully read and followed. Take Complera as prescribed by your doctor. Talk to your doctor or pharmacist about any questions or concerns you may have about the medication.

Adult and pediatric patients who weigh 35 kg or more are recommended to take one tablet by mouth once daily with food. 

Fact Table


Emtricitabine: C8H10FN3O3S Rilpivirine: C22H18N6O Tenofovir Disoproxil Fumarate: C19H30N5O10P


Approved by the FDA and EMA for the treatment of HIV


Emtricitabine: 93% Rilpivirine: 33% (under fasting conditions) Tenofovir Disoproxil Fumarate: 25% (boosted to 39% with a high-fat meal)

Legal status


Chemical Name

Emtricitabine / Rilpivirine / Tenofovir Disoproxil Fumarate

Elimination half-life

Emtricitabine: 10 hours Rilpivirine: 45 hours Tenofovir Disoproxil Fumarate: 14-17 hours

Dosage (Strength)

200mg / 25mg / 300mg


Consult doctor



Protein binding

Emtricitabine: 4% Rilpivirine: 99.7% Tenofovir Disoproxil Fumarate: 0.7% to 7.2%

PubChem CID

Emtricitabine: 60877 Rilpivirine: 6451161 Tenofovir Disoproxil Fumarate: 5481350




Emtricitabine: 31552 Rilpivirine: 59527 Tenofovir Disoproxil Fumarate: 63625

ATC code



Emtricitabine: DB00879 Rilpivirine: DB08864 Tenofovir Disoproxil Fumarate: DB00300


Emtricitabine: D01199 Rilpivirine: D09727 Tenofovir Disoproxil Fumarate: D01982

Routes of administration



Each Complera tablet contains two nucleoside analog HIV-1 reverse transcriptase inhibitors, emtricitabine and tenofovir disoproxil fumarate, and one non-nucleoside reverse transcriptase inhibitor, rilpivirine.


Do not take Complera with medications that can decrease its response to HIV-1 or cause medication resistance. These medications include carbamazepine, phenobarbital, phenytoin, rifampin, rifapentine, dexamethasone, St. John's wort, dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole. Ask your doctor if you do not know whether or not you take any of these medications.


Complera contains a FDA Boxed Warning regarding severe worsening of hepatitis B virus (HBV) in patients with HIV-1 and HBV who stopped taking medications containing emtricitabine and/or tenofovir disoproxil fumarate.

  • Before you begin taking Complera, talk to your doctor:
    • About all the medications you take, including prescription and over-the-counter medications
    • About your allergies
    • About your health history and medical problems
    • About your pregnancy or breastfeeding status
  • Complera may cause allergic reactions, including fever, rash, blisters, and swelling.
  • Liver problems can occur with the use of Complera, especially in patients who have hepatitis B or C or elevated liver enzymes.
  • Depression and other mood changes can occur with the use of Complera.
  • Complera may cause kidney problems; therefore, patients with moderate or severe kidney problems should not take the medication. 
  • Complera may cause a decrease in bone mineral density. 
  • A serious abnormal heart rhythm called Torsades de Pointes can occur if patients take Complera with medications that can prolong the QTc interval.
  • Complera may cause life threatening lactic acidosis and liver enlargement with extra fat in the liver.
  • Complera can cause problems with the immune system.

Side Effects

Common Complera side effects include depression, headache, trouble sleeping, abnormal dreams, dizziness, nausea, and rash. However, these are not all the side effects that may occur.

Contact your doctor right away if you have side effects that are bothersome or persistent.


  1. Complera (emtricitabine, rilpivirine, tenofovir disoproxil fumarate) tablets, for oral use. Foster City, CA: Gilead Sciences, Inc.; 2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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