Combipatch (Estradiol / Norethindrone Acetate)

Also Known as Estalis Continuous

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


CombiPatch is a transdermal patch that's made up of hormones to treat menopausal symptoms, vaginal atropy due to menopause, and low estrogen levels caused by hypogonadism, castration, or primary ovarian failure in women with a uterus.

The hormones in CombiPatch are estradiol and norethindrone acetate.

CombiPatch is supplied in the following strengths:

  • 0.05 mg estradiol with 0.14 mg norethindrone acetate
  • 0.05 mg estradiol with 0.25 mg norethindrone acetate

Fact Table




US DailyMed


50% - 100%

Legal status


Chemical Name

Estradiol/norethisterone acetate

Elimination half-life

12-14 hours

Dosage (Strength)

50mcg/140 mcg, 50mcg/250mcg


Consult Doctor



Protein binding

37- 61%

PubChem CID






ATC code






Routes of administration



The instructions that come with your CombiPatch prescription should be carefully read and followed. Use CombiPatch as prescribed by your doctor. Talk to your doctor or pharmacist about any questions or concerns you may have.


Apply CombiPatch to smooth, clean, dry, and undamaged skin of the lower abdomen. Avoid placing the patch on or near the breasts or at the waistline where clothing could rub it off. It's recommended that you rotate the application sites, allowing at least one week between applications to the same site. Only one patch at a time should be worn during the 3- or 4-day dosing interval. Do not expose the patch to the sun for long periods of time.


Remove the patch slowly. If there is adhesive still stuck to the skin, allow your skin to dry for 15 minutes, then gently rub the area with an oily cream or lotion to remove it.

Store CombiPatch systems in their sealed foil pouches in the refrigerator between 36°F and 46°F. Keep CombiPatch out of reach of children and pets.


Each CombiPatch transdermal system contains estradiol and norethindrone acetate.


Avoid using CombiPatch if you have any of the following:

  • Abnormal, undiagnosed vaginal bleeding 
  • Current, suspected, or a history of breast cancer
  • Current or suspected estrogen-dependent cancer
  • Current or a history of blood clots in the legs or lungs
  • Active stroke or heart attack
  • Previous allergic reaction or swelling associated with CombiPatch
  • Liver disorders
  • Blood clotting disorders, including protein C, protein S, or antithrombin deficiency
  • Pregnant


CombiPatch has a FDA Boxed Warning against the use of estrogens and progestins for preventing cardiovascular disease or dementia. The FDA Boxed Warning also warns that estrogen plus progestin therapy can increase the risk of blood clots in the legs or lungs, stroke, and heart attack in postmenopausal women. Further, the FDA Boxed Warning warns that estrogen plus progestin therapy can increase the risk of dementia and breast cancer in women. Estrogen alone has been shown to increase the risk of endometrial cancer in women with a uterus. Estrogen alone has also been shown to increase the risk of stroke, blood clots, and dementia in postmenopausal women. Estrogens with or without progestins should be used at the lowest dose possible and for the shortest duration of time while meeting treatment goals.

  • Before you use CombiPatch, tell your doctor about:
    • All the medications you take
    • Your allergies
    • Your health history and medical problems
    • Your pregnancy or breastfeeding status
  • Postmenopausal women who take estrogens may be at increased risk of gallbladder disease that requires surgery.
  • Women who take estrogens and have breast or bone cancer may be at risk for high calcium levels.
  • Estrogens can cause blood clots in the retina of the eyes.
  • CombiPatch may cause swelling of the eyes, face, tongue, legs, ankles, or fingers. Seek medical care right away if you experience any of these effects.
  • CombiPatch may cause severe allergic reactions that include hives, itching, or swelling. Seek medical care immediately if you experience any of these effects.
  • Blood pressure may increase with estrogen use.
  • Triglyceride levels in the blood that can lead to pancreatitis may increase with the use of estrogens.
  • A dose increase in hormone replacement therapy may be required in women who are also taking estrogens.
  • Estrogens can cause fluid retention.
  • Conditions such as asthma, diabetes, seizures, migraines, lupus, and benign liver tumors may worsen with estrogen use. Women with any of these conditions should use CombiPatch with caution.

Side Effects

Stomach pain, diarrhea, depression, sore throat, application site reactions, breast pain, and vaginal inflammation are some of CombiPatch's side effects. However, these are not the only side effects that may develop.

Call your doctor immediately if you have bothersome or persistent side effects.


  1. CombiPatch (estradiol/norethindrone acetate transdermal system). Miami, FL: Noven Pharmaceuticals, Inc.; 2021.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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