Canada Drugs Direct

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Combipatch (Estradiol / Norethindrone Acetate)

Known as Estalis Continuous in the UK

Prescription medicineOnly Available By Prescription

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You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


CombiPatch is a transdermal hormone therapy (HT) patch that contains both estrogen and progestin and is designed specifically for postmenopausal women who still have their uterus. When applied just twice a week, CombiPatch helps to treat moderate to severe hot flashes, night sweats, and vaginal dryness associated with menopause. You and your healthcare provider should talk regularly about whether you still need treatment with CombiPatch to control these problems. If you use CombiPatch only to treat menopausal changes in and around your vagina, talk with your healthcare provider about whether a topical vaginal product would be better for you. CombiPatch is a small and discreet patch, and using its innovative Delivery Optimized Thermodynamics (DOT) Matrix™ technology, provides a continuous release of hormones through your skin and directly into your bloodstream. That means you can get effective symptom relief and a smaller daily dose of hormones than with HT pills. This difference does not mean that CombiPatch is safer or more effective than hormone therapy pills or other hormone therapies. CombiPatch also provides options for you and your doctor. Learn about two dosing regimens, what bleeding patterns you can expect, and how you and your doctor can work together to meet your changing needs.


Home What Makes CombiPatch Different? How CombiPatch Works CombiPatch Dosing Regimens Continuous Combined Regimen Continuous Sequential Regimen How to Use CombiPatch Questions to Ask Your Doctor FAQs About Menopause Savings Pay As Little As $25* Start saving ? *See full program terms and conditions, including max benefit, on the CombiPatch Copay Savings Offer. How to Use CombiPatch® It's easy to use CombiPatch. Just follow these steps. 1. Use the calendar to the right to choose which two days of the week you are going to change your patch. Your CombiPatch individual carton contains a calendar card printed in its inner flap. Mark the two-day schedule you plan to follow on your carton's inner flap. Be consistent. If you forget to change your patch on the correct date, apply a new one as soon as you remember. No matter what day this happens, stick to the schedule you have marked on the inner flap of your carton (your calendar card). 2. Before you apply the CombiPatch System, prepare your skin. Make sure your skin is: Clean (freshly washed), dry and cool. Free of any powder, oil, moisturizer or lotion. Free of cuts and or irritations (rashes or other skin problems).


Estradiol/Norethindrone acetate

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