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Combigan (Brimonidine / Timolol)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
0.2%-0.5% 5ml
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
0.2%/0.5% 5ml
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


COMBIGAN (Brimonidine/Timolol) eye drops is a medication prescribed to treat increased intraocular pressure in patients with glaucoma or ocular hypertension. COMBIGAN is a combination product that contains both brimonidine and timolol, which work by different mechanisms.

Glaucoma is a disease of the optic nerves and if left untreated can lead to irreversible loss of vision. Increased intraocular pressure is one of the risk factors for glaucoma, and if treated can help prevent optic nerve damage.

Fact Table


Brimonidine: C11H10BrN5
Timolol: C13H24N4O3S


FDA approved


Brimonidine: Topically in the eye, not systemically quantified
Timolol: 60-80% (ocularly applied)

Legal status

Prescription only

Chemical Name

Brimonidine / Timolol

Elimination half-life

Brimonidine: 2-3 hours
Timolol: 4 hours

Dosage (Strength)

Brimonidine 0.2% / Timolol 0.5%, Ophthalmic solution

Pregnancy advice

Category C (Risk not ruled out)



Protein binding

Brimonidine: 29%
Timolol: 60%

PubChem CID

Brimonidine: 2435
Timolol: 33624




Brimonidine: CHEBI:3170
Timolol: CHEBI:9599

ATC code



Brimonidine: DB00484
Timolol: DB00373


Brimonidine: D07540
Timolol: D00603

Routes of administration

Topical (ocular)


Instill one drop of COMBIGAN to the affected eye(s) twice daily. Application of COMBIGAN should be separated from other eye drops by at least 5 minutes.

For those who wear contact lenses, they should not be inserted until 15 minutes after using COMBIGAN. 


Brimonidine tartrate

Brimonidine works by activating alpha-adrenergic receptors on the surface of ciliary body cells. By activating these receptors, brimonidine reduced the produces of aqueous humor, lowering the pressure inside the eye.

Timolol maleate 

Timolol also works at the ciliary body cells and blocks the activation of beta-adrenergic receptors, which reduces the production of aqueous humor and has the downstream effect of lowering intraocular pressure.

Inactive ingredients of COMBIGAN include benzalkonium chloride (antibacterial agent), hydrochloric acid (for pH balance), sodium hydroxide (for pH balance), sodium phosphate monobasic and dibasic, and water.


Do not touch the tip of the COMBIGAN eyedropper to the eye or other nonsterile surfaces, as it can contaminate the product. Contaminated products have been reported to cause bacterial infection.

There is a chance that ophthalmic products can be absorbed into the systemic circulation. In that case of beta-blockers like timolol, systemic side effects may include cardiac failure, pulmonary disease, vascular insufficiency, muscle weakness, masking of low blood sugar, and thyroid disorders. If you notice systemic side effects of COMBIGAN, stop the product and speak with your prescriber immediately.

Side Effects

The most common side effects of COMBIGAN include:

  • Allergic conjunctivitis
  • Conjunctival hyperemia
  • Conjunctival folliculitis
  • Ocular burning
  • Pruritis

COMBIGAN side effects on the kidney have been studied and are minimal because the drops are not readily absorbed systemically. Other systemic side effects are also rare.

You can buy COMBIGAN eye drops online with a valid prescription. Read COMBIGAN reviews and buy COMBIGAN eye drops on Canada Drugs Direct without waiting in line at the drug store.


  1. DailyMed. "Combigan Package Insert.". Published 2015. Accessed November 7, 2019.
  2. Weinreb RN, Aung T, Medeiros FA. "The Pathophysiology and Treatment of Glaucoma." JAMA. 2014;311(18):1901. doi:10.1001/jama.2014.3192

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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