Colcrys (Colchicine)

Also Known as Colgout

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


COLCRYS (Colchicine) is a medication prescribed to treat gout flares and Familial Mediterranean fever (FMF). COLCRYS may also be used to prevent the recurrence of gout flares while initiating other medications that lower uric acid.

COLCRYS works by blocking the assembly of microtubules in certain cells of the immune system. Microtubules make up the internal "skeleton" of the cell. By disrupting their formation, COLCRYS prevents the activation of immune cells within the joints that normally lead to gout symptoms. COLCRYS works via a similar mechanism in FMF.

Fact Table




FDA approved


45% (oral)

Legal status

Prescription only

Chemical Name


Elimination half-life

26.6 - 31.2 hours

Dosage (Strength)

0.6 mg tablets

Pregnancy advice

Use only if clearly needed and the potential benefits outweigh the risks. Consult a healthcare provider.


Colcrys, Mitigare

Protein binding


PubChem CID






ATC code






Routes of administration

Oral, Intravenous (for acute gout only)


COLCRYS comes in COLCRYS 0.6 mg tablets. COLCRYS 0.5 mg is available in countries other than the United States, and generally, these dosages are prescribed interchangeably.

The normal dosage of COLCRYS varies based on which condition is being treated:

  • Gout flares, treatment: Take 1.2 mg at the first sign of a gout flare, and then 0.6 mg one hour later
  • Gout flares, prevention: Take 0.6 mg once or twice daily. The duration of therapy may last between 3 to 6 months.
  • FMF: Adults and children older than 12 years old should take 1.2 mg to 2.4 mg daily. The dose is lower for children based on their age.


The active ingredient in COLCRYS is colchicine, which is also the name for COLCRYS generic.


COLCRYS has many potential drug-drug interactions. It can interact with P-GP and CYP3A4 inhibitors. Tell your doctor or pharmacist your whole list of medications before beginning COLCRYS to ensure there are no harmful drug-drug interactions.

Use COLCRYS with caution in patients with a history of kidney impairment or kidney failure. The dose may need to be adjusted.

COLCRYS should not be used by women who are pregnant or breastfeeding.

Side Effects

The most common adverse reactions that occur when taking COLCRYS include:

  • Abdominal pain
  • Diarrhea
  • Diarrhea
  • Nausea
  • Pharyngolaryngeal pain
  • Vomiting


  1. Celebrex [package insert]. New York, NY: Pfizer; 2008.
  2. Gout, Mayo Clinic, March 1st, 2019. Retrieved May 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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