Brisdelle (Paroxetine)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Brisdelle (Paroxetine) is a medication used by women experiencing menopause to treat moderate to severe hot flashes.

Fact Table




US FDA, US DailyMed


about 50%

Legal status


Chemical Name


Elimination half-life

21 hours

Dosage (Strength)



not recommended



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


Brisdelle comes in capsules of 7.5 mg.

The typical dose is 7.5 mg by mouth at bedtime.


Paroxetine is the active ingredient in Brisdelle.


Avoid taking Brisdelle with monoamine oxidase inhibitors or within a 2-week period of using a monoamine oxidase inhibitor. 

Avoid taking Brisdelle with thioridazine.

Avoid taking Brisdelle with pimozide.

Avoid taking Brisdelle if you are allergic to paroxetine or any other ingredient in Brisdelle.

Avoid taking Brisdelle if you are pregnant.



See full prescribing information for complete boxed warning.

  • Potential for increased risk of suicidal thinking and behavior
  • Monitor for worsening and emergence of suicidal thoughts and behaviors
  • Before taking Brisdelle, inform your doctor:
    • Of any allergies you may have
    • About any medications you take, including prescription, non-prescription, vitamins, and herbal supplements
    • About any health conditions you have
    • If you are pregnant or plan to become pregnant
    • If you are breastfeeding or plan to breastfeed
  • Brisdelle can increase the possibility of suicidal thoughts and/or actions. Immediately tell your doctor if you experience suicidal thinking, ideations, or behavioral shift.
  • Your risk for serotonin syndrome may increase while taking Brisdelle. Immediately get medical attention if you experience agitation, restlessness, difficulty sleeping, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle twitching or rigidity, excessive sweating, diarrhea, headache, shivering, or goosebumps. 
  • Brisdelle can reduce the effects of Tamoxifen.
  • Abnormal bleeding risk increases while taking Brisdelle and non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, or other drugs that increase the risk of bleeding. Be aware of signs of bleeding such as bleeding from the nose, bleeding gums, or blood in your stools.
  • Let your doctor know if you have vision problems such as glaucoma.
  • Let your doctor know if you experience seizures, or you have a condition that can cause seizures.
  • Low sodium levels in the blood can be caused by Brisdelle. Seek medical attention right away if confusion, nausea, vomiting, energy loss, drowsiness, mood changes, restlessness, muscle weakness, muscle spasms or cramps, or seizures occur. 
  • Risk for bone fractures can be increased by Brisdelle.
  • Mania or hypomania can be caused by Brisdelle.
  • Restless tendencies can be caused by Brisdelle.
  • Sexual dysfunction can be caused by Brisdelle.
  • Avoid operating heavy machinery until you know how you react to Brisdelle.

Side Effects

The most common side effects associated with Brisdelle consist of headache, fatigue, nausea, and vomiting. Inform your doctor immediately if you experience bothersome or continuous side effects.


  1. Brisdelle Prescribing Information. Roswell, GA: Sebela Pharmaceuticals, Inc.; 2021. 
  2. Serotonin syndrome. Mayo Clinic. January 22, 2022. Accessed February 4, 2022. 
  3. Hyponatremia. Mayo Clinic. May 23, 2020. Accessed February 4, 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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