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Brenzys (Etanercept)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Your doctor may prescribe Brenzys for managing different inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.

Brenzys (generic name etanercept) is a p75 tumor necrosis factor (TNF) receptor administered via subcutaneous injections. After dissolving in the bloodstream, it binds to TNF alpha and TNF beta upon entering the bloodstream, neutralizing biological TNF. This molecular modulation results in the attenuation of the inflammatory response.


Typically, the dosage is 25-50 mg injected under the skin once weekly. The dosage varies based on which condition is being treated and other factors.

Do not stop or change the dosage without talking to your doctor.


The active ingredient in Brenzys is etancercept.


Common drug-drug interactions with this medication may include:

  • Abatacept
  • Adenovirus Vaccine
  • Anakinra
  • Anifrolumab-fnia
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Baricitinib
  • Cholera Vaccine, Live
  • Cyclophosphamide
  • Dengue Tetravalent Vaccine, Live
  • Infliximab
  • Influenza Virus Vaccine, Live
  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Poliovirus Vaccine, Live
  • Rilonacept
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine, Live
  • Varicella Virus Vaccine, Live
  • Vedolizumab
  • Yellow Fever Vaccine
  • Zoster Vaccine, Live


Tell your doctor if you have a history of tuberculosis (TB) infection before starting Brenzys. This drug can reactivate latent TB infections.

Brenzys may weaken your immune system and leave you more susceptible to infectious diseases.

Side Effects

The most common adverse reactions to this drug may include the following:

  • Aplastic anemia
  • Autoimmune hepatitis
  • Cancer
  • Congestive heart failure
  • Demyelinating disease of the central nervous system
  • Erythema multiforme
  • Hepatosplenic T-cell lymphoma
  • Hypersensitivity reaction
  • Infectious disease
  • Injection site disorder
  • Leukemia
  • Malignant lymphoma
  • Melanoma
  • Multiple sclerosis
  • Necrotizing fasciitis
  • Optic neuritis
  • Pancytopenia
  • Peripheral demyelinating neuropathy
  • Primary cutaneous vasculitis
  • Reactivation of hepatitis B viral hepatitis
  • Seizure
  • Skin cancer
  • Squamous cell carcinoma of the skin
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Transverse myelitis, acute
  • Tuberculosis
  • Upper respiratory infection


Brenzys [package insert]. Kirkland, QC, Canada: Merck; August 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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