Bexacat (Bexagliflozin)

Also Known as Bexacat

Prescription medicineOnly Available By Prescription

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Strength Pack Size Qty
Strength
15mg flavored tablets
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Qty
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Bexacat is a medicine used to help control diabetes in cats. It works by stopping the kidneys from absorbing sugar back into the body, allowing extra sugar to be cleared through the urine. This helps lower the amount of sugar in a cat’s blood. Vets usually prescribe Bexacat for cats that are otherwise healthy, have just been diagnosed with diabetes, and have not been treated with insulin before.

Fact Table

Formula

C24H27ClO5S

License

US FDA (Veterinary Use Only)

Bioavailability

Data not publicly available for feline use

Legal status

Veterinary prescription only (Rx-only, cats only)

Chemical Name

(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-ethoxyphenyl)thio]methyl]phenyl]-D-glucitol

Elimination half-life

Approximately 6–10 hours (based on animal studies)

Dosage (Strength)

15 mg tablet (once daily, cats =6.6 lbs)

Pregnancy

Not for use in breeding, pregnant, or lactating animals

Brands

Bexacat

Protein binding

~94% (in vitro, human plasma)

PubChem CID

49801913

MedlinePlus

Not applicable (veterinary use only)

ChEBI

Not available

ATC code

Not assigned (veterinary use only)

DrugBank

DB16697

KEGG

Not listed

Routes of administration

Oral (tablet, cats only)

Directions

Bexacat is given as an oral tablet once daily, ideally at the same time each day. The standard dosage is 15 mg per tablet for cats weighing 3 kg or 6.6 lbs. Owners should follow the instructions provided by their veterinarian. Bexacat can be given with or without food. Caregivers should not split or crush the tablet.

Ingredients

Bexacat contains the active ingredient Bexagliflozin.

Contraindications

Avoid giving this medication if any of the following apply:

  • The cat has diabetes mellitus and has previously been treated with insulin, is currently receiving insulin, or has insulin-dependent diabetes mellitus
  • The cat shows evidence of hepatic (liver) disease
  • The cat has reduced renal (kidney) function
  • The cat is not eating, very tired, or dehydrated

Cautions

  • Before giving Bexacat, you may want to consult a veterinarian about the following:
    • Any existing health conditions
    • Any allergies
    • A list of all medications currently being taken
  • Bexacat is only for use in cats. It should never be taken by people. If a person accidentally swallows it, they should contact a doctor right away. Always keep it out of reach of children.
  • Cats with hidden kidney or liver issues may have trouble clearing Bexacat from their system. This can cause long-lasting effects like excessive sugar in the urine or dehydration, even after stopping the medication. In some cases, these cats may need to be hospitalized.
  • Cats should be checked and treated for urinary tract infections (UTIs) before starting Bexacat, and monitored closely during treatment. If UTIs keep coming back, your vet may need to stop the medication.
  • Bexacat may raise calcium levels in the blood, which could lead to bladder stones. Cats with high calcium should stop using Bexacat.
  • Long-term use might increase the risk of certain bladder cancers.
  • The medication may also lead to increased hunger, thirst, or urination in some cats, even when blood sugar levels are under control.
  • If your cat gets diarrhea that doesn’t go away with regular treatment, Bexacat may need to be stopped.
  • During times of low appetite (like after surgery or illness), Bexacat might raise the risk of serious problems like liver disease or diabetic ketoacidosis (DKA).
  • Accidental weight gain can happen due to increased hunger caused by sugar loss in the urine.
  • Bexacat hasn’t been tested in pregnant, nursing, or breeding cats, so it should be avoided in those cases.
  • Keep the medication in a safe place to prevent other pets from eating it by mistake.

Side Effects

In clinical studies, the most common side effects reported in cats taking Bexacat included vomiting, diarrhea, increased thirst, decreased appetite, lethargy, and weight loss. Many cats also showed temporary increases in lab values such as BUN and pancreas-specific lipase, often linked to dehydration or glucosuria. Some cats experienced urinary tract infections, increased liver enzymes, or behavioral changes like hiding or agitation. Most side effects were mild to moderate and did not require stopping treatment.

However, serious adverse reactions occurred in a small number of cats, including DKA, pancreatitis, hepatic lipidosis, and euglycemic DKA. In both short- and long-term studies, some cases resulted in death or euthanasia, especially when symptoms developed within the first few doses. Affected cats often required emergency care or were transitioned to insulin therapy. Cat owners should watch closely for any signs of vomiting, poor appetite, or lethargy during the first few weeks of treatment and contact their veterinarian immediately if serious side effects occur.

References

  1. Bexacat (Bexagliflozin) Drug Label Information. Greenfield, IN: Elanco US Inc.; 2022.


IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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