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Bosulif (Bosutinib)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Bosulif, or Bosutinib, is a tyrosine kinase inhibitor for treating adult patients with chronic, accelerated, or blast-phase Philadelphia-chromosome-positive chronic myelogenous leukemia (CML).

It works by interfering with the abnormal signals responsible for the growth of cancer cells. This medication is often part of a comprehensive treatment plan for patients with certain forms of leukemia.


The starting dosage is 500 mg once daily and can be adjusted to 200-600 mg daily based on patient factors.


The active ingredient in Bosulif is bosutinib.


Common drug-drug interactions may include:

  • Adagrasib
  • Adenovirus Vaccine
  • Amprenavir
  • Aprepitant
  • Asciminib
  • Atazanavir
  • Avacopan
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Belzutifan
  • Boceprevir
  • Carbamazepine
  • Ceritinib
  • Cholera Vaccine, Live
  • Cimetidine
  • Ciprofloxacin
  • Clarithromycin
  • Clofazimine
  • Cobicistat
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Dabrafenib
  • Daridorexant
  • Darunavir
  • Dengue Tetravalent Vaccine, Live
  • Dexlansoprazole
  • Diltiazem
  • Dronedarone
  • Duvelisib
  • Enzalutamide
  • Erythromycin
  • Esomeprazole
  • Fedratinib
  • Fexinidazole
  • Fluconazole
  • Fluvoxamine
  • Fosamprenavir
  • Fosnetupitant
  • Fosphenytoin
  • Idelalisib
  • Imatinib
  • Indinavir
  • Influenza Virus Vaccine, Live
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lanreotide
  • Lansoprazole
  • Larotrectinib
  • Lefamulin
  • Lenacapavir
  • Letermovir
  • Levoketoconazole
  • Lonafarnib
  • Lorlatinib
  • Lumacaftor
  • Mavacamten
  • Measles Virus Vaccine, Live
  • Mifepristone
  • Mitotane
  • Mumps Virus Vaccine, Live
  • Nefazodone
  • Nelfinavir
  • Netupitant
  • Nilotinib
  • Nirogacestat
  • Olutasidenib
  • Omaveloxolone
  • Omeprazole
  • Pacritinib
  • Pantoprazole
  • Phenobarbital
  • Phenytoin
  • Pirtobrutinib
  • Poliovirus Vaccine, Live
  • Posaconazole
  • Primidone
  • Rabeprazole
  • Repotrectinib
  • Ribociclib
  • Rifampin
  • Rifapentine
  • Ritlecitinib
  • Ritonavir
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Saquinavir
  • Schisandra sphenanthera
  • Smallpox Vaccine
  • St John's Wort
  • Telaprevir
  • Telithromycin
  • Tocilizumab
  • Trofinetide
  • Troleandomycin
  • Tucatinib
  • Typhoid Vaccine, Live
  • Varicella Virus Vaccine, Live
  • Verapamil
  • Vonoprazan
  • Voriconazole
  • Voxelotor
  • Yellow Fever Vaccine
  • Zoster Vaccine, Live


Tell your doctor if you have a history of chronic infection, gastrointestinal problems, fluid retention, or liver problems.

Do not take this drug if you are pregnant or planning to become pregnant.

Side Effects

The most common side effects of this drug include:

  • Abdominal pain
  • Abnormal liver function
  • Acute renal failure
  • ALT/SGPT level raised
  • Angina pectoris
  • Anaphylactic shock
  • Body fluid retention
  • Constipation
  • Cough
  • Decrease in appetite
  • Diarrhea
  • Edema of face
  • Erythema multiforme
  • Fatigue
  • Febrile neutropenia
  • Gastrointestinal hemorrhage
  • Headache
  • Heart failure
  • Myocardial ischemia
  • Nausea
  • Pancreatitis
  • Peripheral edema
  • Pericardial effusion
  • Pericarditis
  • Pleural effusion
  • Prolonged QT interval
  • Pulmonary edema
  • Pulmonary hypertension
  • Rash
  • Renal impairment
  • Respiratory failure
  • Respiratory tract infection
  • Right bundle branch block
  • Sinus tachycardia
  • Stevens-Johnson syndrome
  • Tachycardia
  • Thrombocytopenia
  • Vomiting


Bosulif [package insert]. New York, NY: Pfizer; September 2012.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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