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400mg
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800mg
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Bonefos (Clodronate Disodium) is a bisphosphonate medication used to manage problems with the bones. It works by slowing down the cells that break down bone, which helps keep bones strong. Doctors often prescribe Bonefos to treat high calcium levels caused by cancer (hypercalcemia of malignancy). It can also be used alongside other treatments to help manage bone loss that happens when cancer spreads to the bones. Bonefos may help stop bone loss and lower the risk of fractures.
| Fact Table | |
| Formula | C2H6Cl2Na2O7P2 |
| License | EMA (Europe), not FDA-approved in the US |
| Bioavailability | ~1–3% (oral) |
| Legal status | Rx-only (prescription only) |
| Chemical Name | Dichloromethylene diphosphonic acid, disodium salt |
| Elimination half-life | 2 hours (plasma), prolonged in bone |
| Dosage (Strength) | 400 mg oral capsules; 300 mg/5 mL IV solution |
| Pregnancy | Category C (risk not ruled out) |
| Brands | Bonefos, Clasteon, Loron |
| Protein binding | Low |
| PubChem CID | 5284376 |
| MedlinePlus | Not listed |
| ChEBI | 3730 |
| ATC code | M05BA02 |
| DrugBank | DB00720 |
| KEGG | D07734 |
| Routes of administration | Oral, Intravenous |
Bonefos is taken by mouth in capsule form to help treat high calcium levels or bone problems caused by cancer. The usual dose is 1600 to 2400 mg per day, with a maximum of 3200 mg per day given as a single dose or divided into two doses. Capsules should be swallowed whole with a glass of plain water on an empty stomach, at least two hours before or after food or other oral medications. If dosing twice daily, the second dose should be taken between meals, more than two hours after and one hour before eating, drinking anything other than water, or taking other oral drugs.
Bonefos contains the active ingredient Clodronate Disodium.
Avoid taking or using this medication if any of the following apply:
History of hypersensitivity to the ingredients of the medication or other bisphosphonates
Severe kidney problems
Severe inflammation of the stomach or intestines
Pregnancy
Breastfeeding
Use of other medications in the same class
Before using Bonefos, you may want to consult a healthcare provider about the following:
Any existing health conditions
Any allergies
A list of all medications you are currently taking
Whether you are pregnant or breastfeeding
Bonefos, like other bisphosphonates, may cause a rare condition called osteonecrosis of the jaw (ONJ), especially after dental procedures. Signs can include jaw pain, swelling, or infection. Tell your doctor if you need any dental work or notice changes in your mouth.
Bonefos can lower calcium levels in your blood, especially when given by IV. In some cases, this can cause symptoms like numbness or muscle cramps. It can also affect the kidneys, particularly in people with kidney problems or dehydration.
Bonefos is not recommended during pregnancy or breastfeeding, and it hasn’t been tested in children. Older adults and people with kidney disease may need extra monitoring or dose adjustments. Your doctor may also avoid this medication if you’re severely dehydrated or have problems balancing electrolytes.
In rare cases, Bonefos has been linked to unusual fractures in the thigh bone. These breaks often happen with little or no injury and may be preceded by aching pain in the hip or thigh. If you notice any unusual leg pain, tell your doctor right away.
The most common Bonefos side effects include mild stomach problems such as nausea, vomiting, diarrhea, or stomach pain, especially when taken by mouth. Some people may also experience dry mouth, difficulty swallowing, or mouth irritation. Less commonly, skin rashes or mild changes in liver tests may occur. These symptoms are usually not serious and may go away with continued use.
More serious side effects may include kidney problems, especially with high doses or rapid IV use, and low calcium levels in the blood. Rare cases of bone, joint, or muscle pain, osteonecrosis of the jaw, or unusual thigh bone fractures have been reported. Breathing issues can occur in people with aspirin-sensitive asthma. Talk to your doctor right away if you experience signs of kidney issues, eye inflammation, or jaw pain.
Bonefos Product Monograph. Mississauga, ON: Bayer Inc.; 2017.
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