Banzel (rufinamide)

Also Known as Inovelon

Prescription medicineOnly Available By Prescription
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100mg
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200mg
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400mg
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Description

Banzel (rufinamide) is prescribed as an add-on treatment for seizures in adults and pediatric patients who are one year of age or older with Lennox-Gastaut Syndrome (LGS).

Banzel comes in 200 mg and 400 mg film-coated oral tablets as well as a 40 mg/mL oral suspension.


Fact Table

Formula

C10H8F2N4O

License

US FDA, EU EMA,US FDA

Bioavailability

85%

Legal status

Rx-Only

Chemical Name

rufinamide

Elimination half-life

6–10 hours

Dosage (Strength)

100mg, 200mg, 400mg

Pregnancy

Consult doctor

Brands

Banzel

Protein binding

34%

PubChem CID

129228

MedlinePlus

a609001

ChEBI

Not Assigned

ATC code

N03AF03

DrugBank

Not Assigned

KEGG

D05775

Routes of administration

By mouth

Directions

Take Banzel as your doctor has instructed. If you have any questions or concerns, reach out to your doctor or pharmacist.

Weight determines each pediatric patient’s Banzel dose.

The recommended starting dose in adults is 400 mg to 800 mg by mouth daily in two equally divided doses. The dose may be increased by the doctor as needed, up to 3,200 mg a day, taken in two divided doses.

Ingredients

Rufinamide is the active ingredient in Banzel. Colloidal silicon dioxide, corn starch, crosscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulphate are the inactive ingredients. The film coating of each tablet is composed of hypromellose, iron oxide red, polyethylene glycol, talc, and titanium dioxide.

Microcrystalline cellulose and carboxymethylcellulose sodium, hydroxyethylcellulose, anhydrous citric acid, simethicone emulsion 30%, poloxamer 188, methylparaben, propylparaben, propylene glycol, potassium sorbate, noncrystallizing sorbitol solution 70%, and an orange flavor are the inactive ingredients in the oral suspension formulation.

Contraindications

Banzel should be avoided in patients with Familial Short QT syndrome.

Cautions

  • Before you start taking Banzel, discuss the following with your doctor:
    • All the medications you take, including prescription and over-the-counter medications.
    • Your allergies.
    • Your current health problems and past medical history.
    • If you are pregnant or breastfeeding.
  • The risk of suicidal thoughts or behaviors is increased with Banzel use; therefore, patients should be monitored for worsening depression, suicidal thoughts or behaviors, or unusual mood or behavioral changes.
  • Banzel can make patients feel sleepy, fatigued, or dizzy. Patients may also experience walking problems and poor muscle control while being treated with Banzel.
  • Banzel can shorten the QT interval, and the risk is increased when taken with other medications that can shorten the QT interval. Caution should be used.
  • Banzel treatment can lead to multiorgan hypersensitivity. Fever, rash, lymphadenopathy, and/or facial swelling are signs and symptoms. Patients may also experience liver or kidney inflammation, blood conditions, inflamed heart muscle, and weak, painful, or achy muscles. Seek emergency care immediately if you develop any of these effects.
  • Banzel should be stopped gradually in order to decrease the risk of seizures.

Side Effects

Headache, dizziness, fatigue, drowsiness, and nausea are common Banzel medication side effects; however, these are not the only side effects that may develop. Call your doctor immediately if you experience side effects that bother you or won’t go away.

Reference:

Banzel (rufinamide). Nutley, NJ: Eisai Inc.; 2021.




IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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