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Top brand choice
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500mg
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Top Generic choice
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500mg
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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Azulfidine (Sulfasalazine) is an anti-inflammatory drug classified as a disease-modifying antirheumatic drug (DMARD). It combines a sulfa antibiotic and a salicylate. This medication treats several inflammatory conditions such as ulcerative colitis and rheumatoid arthritis. By reducing inflammation, it helps manage the symptoms associated with these conditions. The medication comes in tablet form, and each tablet contains 500 mg of the active ingredient.
| Fact Table | |
| Formula | C18H14N4O5S |
| License | US FDA |
| Bioavailability | 10–30% (parent compound); active metabolites formed in colon |
| Legal status | Rx-only |
| Chemical Name | 2-Hydroxy-5-[(2-pyridylamino)sulfonyl]benzoic acid |
| Elimination half-life | 5–10 hours (sulfasalazine); 6–15 hours (metabolites) |
| Dosage (Strength) | 500 mg tablets (regular and enteric-coated); max: 3–4 g/day in divided doses |
| Pregnancy | Category B – Caution in late pregnancy (folate interference) |
| Brands | Azulfidine, Azulfidine EN-tabs, Salazopyrin, generic versions |
| Protein binding | ~99% (sulfasalazine) |
| PubChem CID | 5339 |
| MedlinePlus | a682204 |
| ChEBI | 3211 |
| ATC code | A07EC01 |
| DrugBank | DB00795 |
| KEGG | D00197 |
| Routes of administration | Oral |
The dosage of Azulfidine depends on the condition being treated. For adults with ulcerative colitis, the usual starting dose is 3 to 4 grams daily, split into even doses no more than eight hours apart. Starting with a lower dose (1 to 2 grams daily) may help reduce stomach upset.
Children aged 6 and older typically get 40 to 60 mg per kilogram of body weight per day, divided into 3 to 6 doses. Once symptoms improve, the maintenance dose for adults is 2 grams daily, and for children, 30 mg/kg daily in four doses.
For adult rheumatoid arthritis, the recommended dose is usually 2 grams per day in two divided doses, starting lower and increasing gradually to minimize stomach issues. Children with juvenile rheumatoid arthritis are usually given 30 to 50 mg/kg per day (up to 2 grams), also increasing slowly over several weeks.
Tablets should be swallowed whole, after meals, and with water to reduce stomach upset. Always follow your healthcare provider’s instructions and report any side effects; regular check-ups and blood tests may be needed to monitor your response and adjust the dose.
Azulfidine contains the active ingredient Sulfasalazine.
Avoid taking or using this medication if any of the following apply:
Blockage in your intestines (bowels)
Trouble passing urine because of a blockage
A rare blood problem called porphyria
Allergy to the ingredients in Azulfidine, sulfonamides, or salicylates
Before using Azulfidine, you may want to consult a healthcare provider about the following:
Any existing health conditions
Any allergies
A list of all medications you are currently taking
Whether you are pregnant or breastfeeding
Azulfidine may cause serious side effects, especially in people with liver or kidney problems, or blood disorders. Signs like sore throat, fever, yellowing of the skin or eyes, unusual bruising, or extreme tiredness could point to a serious reaction.
Azulfidine can make it easier to get serious infections like pneumonia or sepsis. Tell your doctor if you’ve had frequent infections in the past.
This medicine may affect sperm count and fertility in men, but stopping the drug often reverses this.
If you’re pregnant, trying to get pregnant, or breastfeeding, talk to your doctor. Azulfidine passes into breast milk and may affect your baby. Your doctor will weigh the benefits and risks before prescribing it.
Your doctor may order regular blood and urine tests to check for side effects while you’re on Azulfidine. It's important to drink plenty of water while taking it to avoid kidney stones.
The most common side effects of Azulfidine include nausea, vomiting, loss of appetite, headache, and stomach upset. Some men may also experience reduced sperm count, which is usually reversible. Skin rash, fever, or itching can also occur but are less frequent. Higher doses may increase the chances of side effects.
More serious reactions may include liver damage, blood disorders, or allergic reactions like fever, rash, or swelling. Rarely, Azulfidine has been linked to lung inflammation, severe skin reactions such as Stevens-Johnson syndrome, and kidney problems. Some people may experience changes in mood, nerve issues, or vision changes. Let your healthcare provider know if you notice any unusual or severe symptoms.
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