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Azulfidine EN (Sulfasalazine) Delayed Release

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

Top Generic choice

Strength Pack Size Qty
500mg (Enteric Coated)
Pack Size

You'll have option to make 4 interest-free payments by credit card once your order is confirmed using

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Azulfidine EN is a prescription medication that can be given for the following conditions:

  • Rheumatoid arthritis (RA)
  • Ulcerative colitis (UC)
  • Ankylosing spondylitis (off-label)
  • Crohn disease (off-label)
  • Psoriatic arthritis (off-label)

The above conditions are autoimmune disorders. In this type of condition, the immune system is too active and attacks the cells of the body, leading to a variety of different symptoms.

When ingested, Azulfidine EN converts into the active form 5-aminosalicylic acid (5-ASA). 5-ASA works by reducing inflammation in the intestines and other sites of the body. It is also thought to scavenge free radicals and inhibit tumor necrosis factor (TNF).

Fact Table






Less than 15%

Legal status


Chemical Name


Elimination half-life

5-10 hours

Dosage (Strength)






Protein binding

More than 99.3%

PubChem CID






ATC code






Routes of administration

By mouth


Take Azulfidine EN exactly as prescribed by your doctor. The dosage is different depending on what condition you are treating.

The dosage may vary from Azulfidine 500 mg daily to a maximum of 4000 mg daily.

Azulfidine EN may be taken with or without food.

It may take several weeks for this medication to start taking effect.

Do not crush, chew, or split Azulfidine EN tablets. Tablets are enteric-coated to ensure they reach the small and large intestines.


The active ingredient in Azulfidine EN is sulfasalazine.


  • Cardiac Glycosides
  • Dapsone (Topical)
  • Eltrombopag
  • Folic Acid
  • Local Anesthetics
  • Methenamine
  • Methotrexate
  • Methylfolate
  • Nitric Oxide
  • Nonsteroidal Anti-Inflammatory Agents
  • Prilocaine
  • Sodium Nitrite
  • Thiopurine Analogs
  • Warfarin


Use caution if you have a history of asthma, kidney problems, liver problems, or G6PD deficiency.

Do not use Azulfidine EN if you have a sulfa allergy.

Ask your doctor or pharmacist for a list of precautions that apply to you.

Side Effects

Azulfidine side effects may include:

  • Abdominal pain
  • Abnormal liver function tests
  • Anorexia
  • Cyanosis
  • Dizziness
  • Dyspepsia
  • Fever
  • Gastric distress
  • Headache
  • Hemolytic anemia
  • Leukopenia
  • Nausea
  • Oligospermia
  • Pruritus
  • Skin rash
  • Stomatitis
  • Thrombocytopenia
  • Urticaria
  • Vomiting


Azulfidine EN [package insert]. New York, NY: Pfizer; 2012.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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