Awiqli (Insulin Icodec)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Awiqli (Insulin Icodec) is a next-generation, once-weekly basal insulin analog developed to improve adherence and simplify insulin therapy in adult patients with diabetes. By maintaining stable insulin levels over seven days, Awiqli helps minimize glucose fluctuations and reduces the burden of daily injections. This innovative formulation supports improved lifestyle flexibility for those managing type 1 or type 2 diabetes. Many patients seeking to buy Awiqli find its weekly dosing schedule to be a major benefit compared to conventional basal insulins. Its unique molecular design provides prolonged activity, ensuring a consistent glucose-lowering effect throughout the week.

Fact Table
Formula C267H404N64O76S6
License FDA approved (March 2024)
Bioavailability ~80% (subcutaneous)
Legal status Prescription only (Rx)
Chemical Name Insulin icodec
Elimination half-life ~196 hours (approx. 8 days)
Dosage (Strength) 700 units/mL in pre-filled pens
Pregnancy Consult healthcare provider
Brands Awiqli
Protein binding Low; similar to human insulin
PubChem CID 162199366
MedlinePlus Not assigned
ChEBI Not listed
ATC code A10AE09
DrugBank DB16612
KEGG D12623
Routes of administration Subcutaneous injection

Directions

Administer Awiqli once per week via subcutaneous injection, preferably on the same day each week. Injection sites include the abdomen, thigh, or upper arm, with rotation recommended to reduce the risk of lipodystrophy. Dosage initiation and adjustments should be based on clinical assessment, previous insulin use, and individual blood glucose profiles. When transitioning from another basal insulin, careful planning is required to avoid overlapping effects or hypo-/hyperglycemia. Patients using Awiqli insulin should be instructed thoroughly in proper handling and administration techniques.

Ingredients

Awiqli contains 70 U/mL of insulin icodec, a modified long-acting insulin analog. Additional components include zinc chloride, glycerol, phenol, and water for injection. The solution is sterile, clear, and preservative-free beyond the listed excipients.

Cautions

Awiqli requires careful initiation, especially in individuals with compromised hepatic or renal function, or when switching from daily insulin therapy. Hypoglycemia risk remains a concern and may be amplified by delayed or missed meals, unplanned physical activity, or incorrect dosing. Patient education and regular monitoring are essential. Insurance coverage may vary, and individuals concerned about Awiqli price should consult their healthcare provider or pharmacy for cost-effective access options.

Contraindications

Do not use Awiqli in patients with known hypersensitivity to insulin icodec or its components. It is also contraindicated during active episodes of hypoglycemia. The safety of Awiqli has not been evaluated in children or in the setting of diabetic ketoacidosis.

Side Effects

Reported side effects of Awiqli may include:

  • Low blood sugar (hypoglycemia)
  • Local injection site reactions
  • Weight gain
  • Skin thickening or pitting at injection sites
  • Rare allergic responses

Immediate medical attention is required for any signs of severe allergic reaction or hypoglycemia.

Frequently Asked Questions about Awiqli (insulin icodec)


What is Awiqli (insulin icodec)?

Awiqli is a once-weekly basal insulin analog used to improve glycemic control in adults with diabetes mellitus. It has a longer half-life than daily insulins, allowing for weekly rather than daily injections.


How is Awiqli administered?

Awiqli is administered as a subcutaneous injection once weekly, on the same day each week. It can be injected into the abdomen, thigh, or upper arm.


Can I switch from my daily insulin to Awiqli?

Yes, you can switch from daily insulin to Awiqli under your healthcare provider's guidance. They will provide specific instructions for transitioning and adjusting your dosage.


What are the most common side effects of Awiqli?

Common side effects include hypoglycemia (low blood sugar), injection site reactions, headache, and nausea. As with all insulins, hypoglycemia is the most significant potential side effect.


How should Awiqli be stored?

Unopened Awiqli should be stored in a refrigerator between 36°F to 46°F (2°C to 8°C). Once in use, it can be kept at room temperature (below 86°F/30°C) for up to 4 weeks.


What should I do if I miss a dose of Awiqli?

If you miss a dose, administer it as soon as possible within 3 days after the missed dose. If more than 3 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day.


Can Awiqli be used with other diabetes medications?

Yes, Awiqli can be used in combination with other diabetes medications, including oral antidiabetic drugs and mealtime insulins, as prescribed by your healthcare provider.


How long does it take for Awiqli to start working?

Awiqli has a gradual onset of action. It can take several weeks to reach steady-state levels in the body and achieve optimal blood glucose control.


Do I need to monitor my blood sugar differently when using Awiqli?

You should continue regular blood glucose monitoring as directed by your healthcare provider. More frequent monitoring may be recommended during the transition period to Awiqli.


Is Awiqli suitable for patients with type 1 and type 2 diabetes?

Awiqli is approved for use in adults with both type 1 and type 2 diabetes mellitus who require basal insulin for glycemic control.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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