Auvelity (Dextromethorphan/Buproprion)

Prescription medicineOnly Available By Prescription

Top brand choice

Strength Pack Size Qty
Strength
45mg/105mg
Pack Size
Qty
What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Auvelity (dextromethorphan/bupropion) is an innovative prescription antidepressant approved for adults with major depressive disorder. Unlike traditional antidepressants, it combines two active ingredients to target multiple pathways in the brain, offering faster and more effective relief for depression symptoms. Auvelity medication is valued for improving mood, concentration, and energy in patients seeking better treatment options.

Fact Table

Formula

C18H25NO (Dextromethorphan), C13H18ClNO (Bupropion)

License

US FDA (2022)

Bioavailability

Dextromethorphan: 11%; Bupropion: Unknown

Legal status

Prescription only (Rx)

Chemical Name

Dextromethorphan and Bupropion

Elimination half-life

Dextromethorphan: 2–4 hours; Bupropion: 21 hours (parent), 29–37 hours (active metabolite)

Dosage (Strength)

45 mg dextromethorphan / 105 mg bupropion ER tablet

Pregnancy

Consult a doctor; Bupropion is Pregnancy Category C

Brands

Auvelity

Protein binding

Dextromethorphan: Unknown; Bupropion: 84%

PubChem CID

Dextromethorphan: 5360696; Bupropion: 444

MedlinePlus

a622019

ChEBI

Dextromethorphan: 4470; Bupropion: 3219

ATC code

N06AX62

DrugBank

Dextromethorphan: DB00514; Bupropion: DB01156

KEGG

Dextromethorphan: D07710; Bupropion: D07541

Routes of administration

Oral

Directions

The usual starting dose is one tablet by mouth once daily for three days, then increased to one tablet twice daily. Tablets must be swallowed whole and not crushed, split, or chewed. Patients should follow their doctor’s instructions carefully and should not stop the medication abruptly without consulting their provider.

Ingredients

Each tablet contains two active ingredients: dextromethorphan hydrobromide and bupropion hydrochloride. Additional inactive ingredients are included to stabilize the formulation and aid absorption.

Interactions

Auvelity may interact with monoamine oxidase inhibitors (MAOIs), other antidepressants, antipsychotics, alcohol, and strong CYP2D6 inhibitors. Patients should inform their doctor of all current medications, supplements, and over-the-counter products to avoid potential complications.

Cautions

Patients with a history of seizures, eating disorders, bipolar disorder, or substance withdrawal should discuss risks with their doctor before taking Auvelity. The medication may raise blood pressure and cause insomnia or dizziness. Auvelity cost may vary, but Canada Drugs Direct makes this medication accessible with trusted delivery. Pregnant or breastfeeding women should consult their doctor before use.

Side Effects

Auvelity side effects can include dry mouth, constipation, dizziness, sleep disturbances, fatigue, and sweating. Less common but serious risks include mood changes, high blood pressure, or suicidal thoughts in younger adults. Any unusual or severe reactions should be reported immediately to a healthcare provider.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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