Asendin (Amoxapine)

Prescription medicineOnly Available By Prescription

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We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

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  • We will only match the current advertised price.
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  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Asendin is a prescription medication used to treat Major Depressive Disorder (MDD). It may be prescribed after other antidepressant medications have been tried and failed.

Asendin belongs to the class of antidepressants called tricyclic antidepressants. It works by affecting the neurotransmitters that pass chemical signals between brain cells. 

The neurotransmitters serotonin, norepinephrine, and dopamine are responsible for creating the moods we feel in the brain. Certain people with MDD have low levels of these neurotransmitters, and Asendin helps increase the levels and improve mood.

Fact Table






More than 60%

Legal status


Chemical Name


Elimination half-life

8–10 hours

Dosage (Strength)

25mg, 50mg, 100mg


Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration



The starting dose of Asendin is 25-50 mg by mouth one to three times per day. Your healthcare provider can increase the dose over 1-2 weeks until it becomes effective at treating symptoms.

The usual dosage of Asendin is 200-300 mg divided into two or three doses per day. The maximum is 400 mg total in a day.


Amoxapine is Asendin's active ingredient.


Asendin can interact with any of the following medications:

  • Abiraterone
  • Azelastine
  • Bromperidol
  • Bupropion
  • Cinacalcet
  • Dacomitinib
  • Darifenacin
  • Darunavir
  • Dronedarone
  • Duloxetine
  • Fluoxetine
  • Givosiran
  • Glycopyrrolate 
  • Ipratropium 
  • Levosulpiride
  • Linezolid
  • Lorcaserin
  • Methylene Blue
  • Mirabegron
  • Monoamine Oxidase Inhibitors
  • Orphenadrine
  • Paroxetine
  • Perhexiline
  • Potassium Chloride
  • Pramlintide
  • Quinidine
  • Rolapitant
  • Selegiline
  • Terbinafine (systemic)
  • Thalidomide
  • Thioridazine
  • Tiotropium
  • Tipranavir
  • Umeclidinium

The above list includes severe drug-drug interactions. Tell your doctor and pharmacist about all medications that you are taking.


Do not take monoamine oxidase inhibitors (MAOIs) while taking Asendin. If switching to or from MAOIs, then 14 days should elapse between a dose of each drug. 

Some antidepressants have been associated with negative effects on mood or suicidal thoughts, especially in younger patients.

Ask your doctor about all precautions when starting Asendin.

Side Effects

The most amoxapine common side effects may include:

  • Anxiety
  • Ataxia
  • Blurred Vision
  • Confusion
  • Constipation
  • Diaphoresis
  • Dizziness
  • Drowsiness 
  • Edema
  • EEG pattern changes
  • Excitement
  • Fatigue
  • Headache
  • Increased appetite
  • Increased serum prolactin
  • Insomnia
  • Nausea
  • Nervousness
  • Nightmares
  • Palpitations
  • Restlessness
  • Skin rash
  • Tremor
  • Weakness
  • Xerostomia


Asendin [package insert]. Parsippany, NJ: Watson; 2014.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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