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Lopidine Eye Drops (Apraclonidine)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


IOPIDINE (apraclonidine) is a prescription eye medication that is used to treat open-angle glaucoma. 

Open-angle glaucoma is a condition where fluid builds up in one or both eyes. The increased fluid causes pressure to the optic nerve that can lead to vision damage or blindness. 

IOPIDINE is an alpha-adrenergic agonist. It works by binding to alpha-receptors in the eye and reducing the formation of aqueous humor. The decreased production of fluid reduces intraocular pressure and protects the optic nerve.

Fact Table







Legal status


Chemical Name


Elimination half-life

8 hours

Dosage (Strength)



Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

Topical (ophthalmic solution)


Place one to two drops into the affected eye(s) three times daily as directed by the healthcare provider.

If you wear contact lenses, wait 15 minutes after the application of IOPIDINE to place them.

Avoid touching the tip of the eyedropper to the eye's surface because this can contaminate the medication and lead to eye infections.


Apraclonidine is the active ingredient in IOPIDINE.

Inactive ingredients include benzalkonium chloride, hydrochloric acid, purified water, sodium acetate, sodium chloride, and sodium hydroxide.


Eye medications typically do not interact with other medications because they are not absorbed into the bloodstream. However, tell your healthcare provider if you are taking any of the following:

  • Alcohol
  • Anti-diabetic agents
  • Antihypertensives
  • Barbiturates
  • Beta-blockers
  • Digoxin
  • Monoamine Oxidase Inhibitors (MAOIs)
  • Sedatives
  • Tricyclic antidepressants


Use caution if you have a history of the following conditions: kidney impairment, liver impairment, cardiovascular disease, uncontrolled hypertension, recent heart attack, cerebrovascular disease, Raynaud's disease, or thromboangiitis obliterans.

Side Effects

Apraclonidine side effects may include:

  • Blanching
  • Blurred vision
  • Conjunctivitis
  • Discharge
  • Discomfort
  • Dry eye
  • Dry mouth
  • Eyelid edema
  • Foreign body sensation
  • Hyperemia
  • Pruritus
  • Tearing


Iopidine [package insert].Fort Worth, Texas: Alcon Laboratories; 2016.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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