Anusol HC Ointment (Hydrocortisone / Zinc Sulfate)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Anusol is a non-prescription product used for the treatment of hemorrhoids. It is available over the counter (OTC) and can be purchased without a prescription.

Hemorrhoids are swollen veins in the anus and lower rectum. They can be present on the inside or the outside of the body. Hemorrhoids are common among adults and older adults. They present with several symptoms, including discomfort, pain, redness, swelling, itching, and bleeding.

Hemorrhoids are often caused by straining during bowel movements. They are more common during pregnancy and in obese patients.

Anusol contains the medication hydrocortisone, which is a topical steroid. Steroids reduce the effects of the immune system to reduce redness, swelling, and inflammation. Anusol also causes vasoconstriction, which shrinks the swollen blood vessels.


Apply Anusol to the affected area two to four times daily, depending on the severity of the condition. Continue treatment until the hemorrhoids resolve. Occlusive dressings may be used.

Anusol is for external use only.


The active ingredient in Anusol is hydrocortisone.


Drug-drug interactions may include:

  • Aldesleukin
  • Calcipotriene


Do not use this product for anything other than the treatment of external hemorrhoids. 

Long-term usage of topical steroids can cause side effects, including Cushing's syndrome, hyperglycemia, and glucosuria.

Pediatric patients are more likely to experience systemic absorption and associated side effects.

Stop using Anusol if irritation develops in the area.

If you are pregnant, talk with your doctor before starting this medication. It is not known if this medication is safe to use while breastfeeding.

Side Effects

Common side effects with topical steroids may include:

  • Acneiform eruption
  • Atrophic striae
  • Burning sensation on the skin
  • Folliculitis
  • Hypertrichosis
  • Hypopigmentation
  • Maceration of the skin
  • Miliaria
  • Perioral dermatitis
  • Pruritus
  • Secondary skin infection
  • Skin atrophy
  • Skin irritation
  • Xeroderma


Anusol [package insert]. Bridgewater, NJ: Salix Pharmaceuticals; 2021

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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