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Alhemo (Concizumab)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Alhemo is a biological agent that your hematologist or oncologist may prescribe for treating the hematologic disorder hemophilia B. Patients with this condition have abnormally low blood clotting, leading to an increased propensity for excessive bleeding. Some symptoms are unexplained bleeding, blood in urine or stool, large or deep bruises, and indicators of serious bleeds.

Alhemo's mechanism of action involves binding to the protein TFPI, which regulates blood clot formation under normal circumstances. By inhibiting TFPI, Alhemo enhances blood clotting, thereby mitigating the risk of excessive bleeding.


Alhemo is available in various prefilled syringes, including 15 mg, 60 mg, 150 mg, and 300 mg.

Your specialist will prescribe a predetermined schedule and dosage for administration. After four weeks of treatment, blood tests are conducted to measure Alhemo levels, allowing for dose adjustments if necessary.

In case of a missed dose, consultation with a healthcare professional is recommended.


The active ingredient in Alhemo is concizumab.


There are only a limited number of drug-drug interactions with this medication, including:

  • Activated prothrombin complex concentrates (PCC)
  • Recombinant FVIIa (rFVIIa)
  • rFVIII
  • rFVIX


Alhemo use carries the risk of serious blood clots, potentially resulting in permanent damage or mortality. Individuals with a personal or family history of blood clots should inform their doctors.

Watch for signs and symptoms of blood clots is advised during treatment.

Notably, Alhemo is contraindicated in patients below 12 and during pregnancy.

Women taking Alhemo should employ highly effective birth control methods during treatment and for seven weeks after completion.

Side Effects

Common adverse reactions include:

  • Allergic reaction (hypersensitivity reaction)
  • Blood clots
  • Fever
  • Headache
  • Increase in level of blood clotting component (fibrin D dimer)
  • Increase in level of blood clotting component (prothrombin fragment 1.2)
  • Infections


Alhemo [package insert]. Mississauga, Ontario: Novo Nordisk; March 2023.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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