Aldurazyme (Laronidase)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Aldurazyme (laronidase) is a recombinant form of human a-L-iduronidase, an enzyme deficient in patients with mucopolysaccharidosis I (MPS I), including Hurler, Hurler-Scheie, and Scheie syndromes. It is indicated for the treatment of non-neurological manifestations of MPS I. Laronidase is designed to replace the deficient endogenous enzyme and reduce the accumulation of glycosaminoglycans (GAGs) in tissues, thereby improving pulmonary function, mobility, and reducing hepatomegaly. Due to limited blood–brain barrier penetration, Aldurazyme is not effective for central nervous system (CNS) symptoms of MPS I.

Fact Table

Formula

C5974H9093N1567O1742S34

License

US FDA, EMA

Bioavailability

Not applicable (IV only)

Legal status

Prescription only (Rx-only)

Chemical Name

Laronidase

Elimination half-life

1.5 to 3.6 hours

Dosage (Strength)

0.58 mg/mL solution; 0.58 mg/kg once weekly (IV infusion)

Pregnancy

Consult a doctor (Category B)

Brands

Aldurazyme

Protein binding

Not applicable (recombinant enzyme)

PubChem CID

16132254

MedlinePlus

a604043

ChEBI

139014

ATC code

A16AB05

DrugBank

DB00090

KEGG

D04717

Routes of administration

Intravenous (IV)

Directions

Aldurazyme is administered as a once-weekly intravenous infusion at a recommended dose of 0.58 mg/kg. The infusion should be administered over approximately 3 to 4 hours and may require premedication with antihistamines and/or antipyretics to minimize the risk of infusion-associated reactions. Initial infusions should be given in a clinical setting equipped to manage anaphylaxis and other acute hypersensitivity reactions. Dosage adjustments are not routinely required based on age, but clinical monitoring is essential throughout therapy.

Ingredients

Each vial of Aldurazyme contains 2.9 mg of laronidase in 5 mL of solution (0.58 mg/mL). Inactive ingredients include sodium chloride, sodium phosphate monobasic monohydrate, sodium phosphate dibasic heptahydrate, and polysorbate 80 in water for injection. The solution is preservative-free and requires dilution prior to infusion.

Contraindications

Aldurazyme is contraindicated in patients with known life-threatening hypersensitivity to laronidase or any of the excipients. Use is also contraindicated during acute respiratory illness due to the risk of severe infusion-related reactions.

Cautions

Infusion-associated reactions (IARs), including severe anaphylaxis, have been reported. Patients with compromised respiratory function or preexisting airway disease should be closely monitored during infusions. Pretreatment with antihistamines, antipyretics, or corticosteroids may be necessary, particularly in patients with prior reactions. Anaphylaxis can occur at any time during treatment and may necessitate immediate discontinuation. Long-term immune response, including the development of IgG antibodies to laronidase, may impact efficacy or safety. Use in pediatric populations has demonstrated benefit in delaying progression of somatic symptoms, though early initiation is critical to optimize outcomes.

Side Effects

Common and serious side effects associated with Aldurazyme include:

  • Infusion-associated reactions (e.g., fever, chills, rash)
  • Urticaria
  • Hypotension
  • Dyspnea
  • Nausea and vomiting
  • Abdominal pain
  • Arthralgia
  • Anaphylaxis (rare but potentially life-threatening)
  • Development of anti-drug antibodies

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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