Akeega (Abiraterone/Niraparib)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Akeega, combining niraparib and abiraterone acetate, is an oral medication that targets prostate cancer. As a dual-action tablet, it uses two different mechanisms: niraparib serves as a PARP inhibitor, while abiraterone acetate works as a CYP17 inhibitor. Together, they disrupt cancer cell DNA repair and hormone production, which are necessary for prostate cancer cell survival. Akeega is indicated for adults with BRCA-mutated metastatic castration-resistant prostate cancer. It uses a dual-action approach to manage this aggressive form of cancer when used alongside prednisone.

Fact Table


Abiraterone: C26H33NO2, Niraparib: C19H20N4O


FDA approved


Abiraterone: ~50% (fasting), Niraparib: 73%

Legal status


Chemical Name


Elimination half-life

Abiraterone: 12 to 24 hours, Niraparib: 36 hours

Dosage (Strength)

500 / 50mg, 500 / 100mg


Consult Doctor



Protein binding


PubChem CID

Abiraterone: 132971, Niraparib: 24958200


Abiraterone: a611043


Abiraterone: CHEBI:68639

ATC code

Abiraterone: L02BX03


Abiraterone: DB05812


Abiraterone: D09359

Routes of administration

Oral (both)


Akeega is taken as a once-daily oral tablet, typically consumed in combination with 10 mg of prednisone. Patients typically take the prescribed dosage of 200 mg niraparib/1,000 mg abiraterone acetate daily, preferably at the same time each day. Take Akeega as directed by the healthcare provider until disease progression or if any severe side effects develop. Avoid eating food two hours before and one hour after taking Akeega.


Akeega combines two active ingredients: niraparib and abiraterone acetate.


No contraindications are listed on the FDA label. However, avoid taking this medication if you have a known hypersensitivity to niraparib, abiraterone acetate, or any excipients in the formulation.


  • Before starting Akeega, inform your healthcare provider about:
    • Other medications
    • Any medical conditions you may have
    • Reproductive plans, such as if your partner is pregnant or intends to become pregnant. Akeega may have effects on an unborn baby.
  • There's a risk of developing myelodysplastic syndrome or acute myeloid leukemia, particularly with niraparib, a component of Akeega. This could be serious and even fatal. Regular monitoring for signs of blood toxicity is vital, and if either condition is confirmed, you should stop using Akeega.
  • It's important to frequently check your complete blood counts. This should be done weekly for the first month, bi-weekly for the next two months, monthly for the rest of the year, and afterward as needed.
  • Akeega might cause high blood pressure, low potassium levels, and fluid retention. Especially in the first two months, weekly monitoring is recommended. If you have conditions affected by these symptoms, be particularly vigilant.
  • Liver damage, including severe and fatal cases, has been reported. Regular liver function tests are important, and treatment may need to be adjusted based on these results.
  • Watch for signs of adrenocortical insufficiency, such as unusual fatigue, muscle weakness, and weight loss. In times of stress, an increased dosage of corticosteroids might be necessary.
  • If you're taking diabetes medications, especially thiazolidinediones or repaglinide, be aware that Akeega can cause severe low blood sugar. Regular blood glucose monitoring and possibly adjusting your diabetes medication are important.
  • There's an increased risk of fractures and mortality when Akeega is combined with radium Ra 223 dichloride. This combination is not recommended.
  • Posterior reversible encephalopathy syndrome, a serious condition, has been observed in patients taking niraparib. If diagnosed with this syndrome, stop using Akeega.
  • Akeega can be harmful to unborn babies. If your partner could become pregnant, using effective contraception is crucial during treatment.

Side Effects

Akeega is known to cause various side effects, but not everyone experiences them. Commonly reported are muscle and bone pain, leg or feet swelling, bleeding, tiredness, breath shortness, urinary infections, liver function changes, reduced appetite, cough, constipation, vomiting, sleep difficulties, high blood pressure, dizziness, weight changes, nausea, COVID-19 symptoms, and irregular heartbeat.

More severe side effects requiring immediate medical attention include low blood potassium, fluid retention, high blood pressure, heart issues, and significant liver problems like liver failure, noticeable through skin or eye yellowing and dark urine. Additional serious concerns are adrenal issues, low blood sugar (particularly in diabetic patients), increased bone fracture risks, and posterior reversible encephalopathy syndrome, which affects the brain. Contact a healthcare provider right away if any of these serious side effects develop.


  1. Akeega (Abiraterone/Niraparib) Product Monograph. Horsham, PA: Janssen Biotech; 2023.
  2. Akeega (Abiraterone/Niraparib) Drug Label Information. Horsham, PA: Janssen Biotech; 2023.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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