Aduhelm (Aducanumab)

Prescription medicineOnly Available By Prescription

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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Aduhelm (Aducanumab) is a medication developed for the treatment of Alzheimer's disease, which is characterized by memory loss and cognitive decline. As a type of monoclonal antibody, Aduhelm targets amyloid beta plaques—protein deposits typically found in the brains of people with Alzheimer's—and helps reduce their buildup. Aduhelm may help slow the progression of Alzheimer’s. It falls under the class of monoclonal antibodies.


Aduhelm is administered via intravenous infusion over approximately one hour. Health professionals typically start with an initial dosage of 1 milligram (mg) per kilogram (kg) of the patient's body weight once every four weeks. The dosage gradually increases to 3 mg/kg, then 6 mg/kg, and finally to a maintenance dose of 10 mg/kg based on tolerability.

It’s recommended to undergo monitoring for amyloid-related imaging abnormalities (ARIA) during treatment, which includes MRI scans before the 5th, 7th, 9th, and 12th infusions. Because of potential side effects, caregivers should be attentive to any changes in health and report them to the healthcare provider.


The main ingredient in Aduhelm is aducanumab-avwa. Inactive ingredients may include L-arginine hydrochloride, L-histidine, polysorbate 80, and water for injection, among others.


There are no known contraindications for Aduhelm.


  • Before planning to start Aduhelm, discuss the following with their healthcare provider:
    • Any known allergies to drugs, particularly to other monoclonal antibodies
    • Existing health conditions.
    • Current medications, as they can impact the effectiveness of Aduhelm or increase the likelihood of adverse effects
    • Pregnancy status, intentions of becoming pregnant, or breastfeeding, as it's uncertain whether Aduhelm poses risks to an unborn child or if it can be transferred through breast milk.
  • Aduhelm has been associated with the possibility of amyloid-related imaging abnormalities (ARIA), which are typically symptom-free but may occasionally lead to severe or potentially fatal complications, such as considerable brain bleeding or intracerebral hemorrhage.
  • Patients who are homozygous for the ApoE e4 gene, carrying two copies, are at an increased risk of developing serious ARIA symptoms compared to those who are heterozygous (one copy) or have no copies of the gene. It is recommended to have a discussion about genetic testing for ApoE e4 status to fully understand the risk before beginning treatment. The advantages of Aduhelm in managing Alzheimer's disease should be carefully weighed against the potential ARIA risks.
  • During the initial eight doses of Aduhelm, particularly when increasing the dose, monitoring for ARIA is recommended. Immediate medical attention, including an MRI if needed, may be required if symptoms of ARIA develop.
  • Hypersensitivity reactions, such as swelling or itching, may occur with Aduhelm use. If a hypersensitivity reaction is experienced, discontinue the treatment immediately and seek appropriate medical assistance.

Side Effects

The use of Aduhelm may cause side effects. Common Aduhelm side effects are associated with amyloid-related imaging abnormalities. These side effects may include headaches, confusion, nausea, dizziness, vision changes, and seizures. Monitor these side effects closely as they may indicate the body’s reaction to Aduhelm. Seek medical attention if side effects develop, persist, or worsen.


  1. Aduhelm (Aducanumab) Product Monograph. Cambridge, MA: Biogen Inc; 2023.
  2. Aduhelm (Aducanumab) Drug Label Information. Cambridge, MA: Biogen Inc; 2023.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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