Adlyxin (Lixisenatide)

Description

Adlyxin (Lixisenatide) is a once-daily injectable medication prescribed for adults with type 2 diabetes mellitus. As a glucagon-like peptide-1 (GLP-1) receptor agonist, Adlyxin works by helping the body produce more insulin and slowing down the emptying of the stomach. It is used together with a balanced diet and regular exercise to manage blood sugar levels.

Directions

The initial dose of Adlyxin is 10 mcg, administered under the skin (subcutaneously) once daily for 14 days. Maintenance therapy begins on day 15 with an increased dosage of 20 mcg once daily. It is usually prescribed to be injected within one hour of the first meal of the day. Adlyxin can be injected into the skin of the thigh, upper arm, or stomach area. Always follow your healthcare provider's instructions and adhere to any special dietary guidelines given.

Ingredients

Adlyxin is an injectable prescription medication containing the active ingredient lixisenatide.

Contraindications

Avoid using Adlyxin if you have a severe hypersensitivity or allergy to lixisenatide or any ingredient in Adlyxin.

Cautions

• Before taking Adlyxin, it is important to inform your doctor about:
• Any medications you take, including prescription drugs, over-the-counter medicines, and herbal supplements, especially other diabetes medications, birth control pills, or antibiotics.
• Any medical conditions, including pancreatitis, gallbladder problems, kidney disease, stomach problems, or a history of alcoholism.
• If you are pregnant or plan to become pregnant
• If you are breastfeeding or planning to breastfeed
• Using Adlyxin with medicines like sulfonylurea or insulin could increase your risk of low blood sugar (hypoglycemia). Symptoms may include headaches, dizziness, or weakness. Consult your healthcare provider as you may need to adjust your other medications.
• If you have pre-existing kidney conditions, side effects such as diarrhea and nausea from Adlyxin could worsen your condition due to dehydration.
• Gallbladder issues have been reported by some people taking Adlyxin. Look out for symptoms like abdominal pain or fever, and seek immediate medical attention if these occur.
• Regular check-ups may be necessary when using Adlyxin to keep track of blood sugar levels and the health of your kidneys and gallbladder.

• Never share the Adlyxin pen between patients, even if the needle has been changed.
• Some people may develop antibodies to lixisenatide, which can affect blood sugar control. If this occurs, consider alternative antidiabetic treatments.

Side Effects

As with most medications, some side effects can occur during the use of Adlyxin. The most commonly reported side effects include nausea, vomiting, headache, diarrhea, dizziness, and hypoglycemia.

Monitor these side effects and discuss them with a healthcare professional if they become severe or persistent. In many cases, a healthcare professional can provide advice on ways to prevent or reduce some of these side effects.

Serious side effects may include allergic reactions, kidney problems, and gallbladder problems. Seek immediate medical help if you experience severe side effects, such as difficulty breathing, swelling of the face or throat, severe pain in the upper stomach, rapid heartbeat, or trouble swallowing.

References:

1. Adlyxin Prescribing Information. Bridgewater, NJ: Sanofi-Aventis; 2022.
2. Lixisenatide Injection Drugs, Herbs and Supplements. Bethesda, MD: National Library of Medicine; 2017.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....