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Actoplus Met (Pioglitazone/Metformin)

Also Known as Competact

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Actoplus Met (pioglitazone and metformin hydrochloride) is a combination medication that is prescribed in addition to diet and exercise to treat high blood sugar in adults who have type 2 diabetes.

Actoplus Met is available in oral tablets containing 15 mg pioglitazone/500 mg of metformin HCl and 15 mg pioglitazone/850 mg metformin HCl.


Actoplus Met should be taken exactly as your doctor has advised. Any questions or concerns should be discussed with your doctor or pharmacist.

Depending on your current treatment regimen, your Actoplus Met dosage may be changed based on how well you tolerate and respond to the medication. You should not take more than pioglitazone 45 mg and metformin 2550 mg by mouth a day.


The active ingredients in Actoplus Met are pioglitazone, a thiazolidinedione, and metformin, a biguanide. Inactive ingredients include povidone, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose 2910, polyethylene glycol 8000, titanium dioxide, and talc.


Patients with New York Heart Association Class III or IV heart failure should not take Actoplus Met.

Patients who suffer from severe kidney problems should not take Actoplus Met.

Patients who have an allergy to pioglitazone, metformin, or to any of its other ingredients should avoid taking Actoplus Met.

Patients with diabetic ketoacidosis should not take Actoplus Met.


Actoplus Met has the following FDA Boxed Warnings:

  • Thiazolidinediones (a component of Actoplus Met), can cause or worsen congestive heart failure in some patients.
  • After dose changes and starting treatment with Actoplus Met, patients should be monitored for signs and symptoms of heart failure. If heart failure occurs, it should be managed and Actoplus Met should be stopped or the dose should be reduced.
  • Patients with symptomatic heart failure should not take Actoplus Met.
  • Patients with established New York Association Class III or IV heart failure should not take Actoplus Met.
  • Metformin-associated lactic acidosis can lead to death, hypothermia, low blood pressure, and resistant slow heart rates. Symptoms include general discomfort, muscle pains, breathing problems, drowsiness, and stomach pain. Lab findings may include elevated blood lactate levels, anion gap acidosis, increased lactate:pyruvate ratio, and metformin blood levels greater than 5 mcg/mL.
  • The risk of lactic acidosis is increased in patients with kidney problems, who are taking certain drugs, who are at least 65 years old, who are undergoing radiological studies with contrast, who are undergoing surgery and other procedures, who have low blood oxygen, who consume excessive amounts of alcohol, or who have liver problems.
  • If lactic acidosis is suspected, Actoplus Met should be stopped and treatment started.
  • Before starting Actoplus Met, tell your doctor:
    • About any and all prescription and nonprescription medications you take
    • About any allergies you may have
    • About your past medical history and current health conditions
    • Your current pregnancy and breastfeeding status
  • Fluid retention, which can worsen or result in congestive heart failure, can be caused by Actoplus Met. Monitoring for signs and symptoms is important.
  • Lactic acidosis can be caused by Actoplus Met.
  • Swelling that is dose-related can be caused by Actoplus Met.
  • Low blood sugar levels can occur with the use of Actoplus Met and insulin or an insulin secretagogue; a lower insulin or insulin secretagogue dose may be required.
  • Actoplus Met may cause liver failure that can be fatal.
  • An increased risk of bladder cancer may be associated with Actoplus Met.
  • A female‚Äôs incidence of fracture risk could be increased with Actoplus Met.
  • All diabetic patients are recommended to have regular eye exams, as they are at risk of macular edema with Actoplus Met.
  • Actoplus Met may decrease vitamin B12 levels.
  • There is no evidence that Actoplus Met reduces the risk of macrovascular outcomes.

Side Effects

Upper respiratory tract infection, swelling, diarrhea, headache, and weight gain are side effects associated with Actoplus Met. If you experience concerning or persistent side effects, immediately call your doctor.


Actoplus Met. Lexington, MA: Takeda Pharmaceuticals America Inc.; 2020.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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