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Activella (Estradiol / Norethindrone)

Known as Activelle in the UK

Prescription medicineOnly Available By Prescription
Sezzle

Top brand choice

Strength Pack Size Qty
Strength
LD 0.5/0.1mg 3 months
Pack Size
Qty
Strength
LD 1.0/0.5mg 1 month
Pack Size
Qty
Strength
1.0/0.5mg 3 months
Pack Size
Qty

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Activella (estradiol/norethindrone acetate) is a medication consisting of two hormones to treat moderate to severe symptoms of menopause and vulvar and vaginal atrophy as a caused by menpause in women who have a uterus. Postmenopausal women who have a uterus also take Activella to prevent osteoporosis.

Directions

Follow the instructions on the label of your prescription and read the information that comes with your prescription. 

Activella is available in 1 mg/0.5 mg and 0.5 mg/0.1 mg tablets.

  • Activella 1 mg/0.5 mg or Activella 0.5 mg/0.1 mg tablets are prescribed to treat moderate to severe symptoms of menopause and to prevent osteoporosis in women who have a uterus.
  • Activella 1 mg/0.5 mg is prescribed to treat moderate to severe symptoms of vulvar and vaginal atrophy as a result of menopause in women who have a uterus.

Activella dosage:

Take one tablet by mouth one time a day.

Ingredients

Estradiol and norethindrone acetate are the active ingredients contained in each tablet of Activella. Lactose monohydrate, starch (corn), copovidone, talc, magnesium stearate, hypromellose, and triacetin are the inactive ingredients. The 0.5 mg/0.1 mg also contains hydroxypropylcellulose.

Contraindications

  • Avoid taking Activella if you:
    • have unusual vaginal bleeding without a cause.
    • have, think you have, or have ever had breast cancer.
    • have or suspect that you have estrogen-dependent neoplasia.
    • have an active blood clot or have ever had a blood clot in your veins or lungs.
    • have or have ever had a stroke or heart attack.
    • are allergic to any of the ingredients contained in Activella.
    • have liver conditions.
    • have a blood condition such as protein C, protein S, or antithrombin deficiency.
    • are pregnant or suspect that you are pregnant.

Cautions

WARNING: CARDIOVASCULAR DISORDERS, BREAST CANCER, ENDOMETRIAL CANCER AND PROBABLE DEMENTIA

See full prescribing information for complete boxed warning

Estrogen Plus Progestin Therapy

  • Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia 
  • The Women's Health Initiative (WHI) estrogen plus progestin substudy reported increased risks of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke and myocardial infarction (MI) 
  • The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer
  • The WHI Memory Study (WHIMS) estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmeno- pausal women 65 years of age and older
    Estrogen-Alone Therapy
  • There is an increased risk of endometrial cancer in a woman with a uterus who use unopposed estrogens 
  • Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia 
  • The WHI estrogen-alone substudy reported increased risks of stroke and DVT 
  • The WHIMS estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older
    • Before you start taking Activella, inform your doctor of: 
      • Any medications you take
      • Your allergies
      • Your medical problems and medical history
      • Your pregnancy or breastfeeding status and/or plans
    • Activella can increase your risk for gallbladder disease.
    • If you lose your vision or experience other vision problems while taking Activella, seek medical attention right away.
  • If you experience yellowing of your skin or the whites of your eyes while taking Activella, seek medical medical attention right away. 
  • High calcium levels in the blood can occur in women who take Activella and have breast cancer or bone cancer. 
  • High blood triglyceride levels that can cause pancreatitis can occur during treatment with Activella.
    • High blood pressure can occur during treatment with Activella.
  • Your thyroid function should be checked during treatment with Activella if you are taking thyroid replacement.
  • Low blood calcium levels can occur in women who have hypoparathyroidism and take Activella. 
  • Fluid retention can occur during treatment with Activella.
  • The symptoms of certain conditions, including hereditary angioedema, asthma, diabetes, epilepsy, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas can occur during treatment with Activella. Women who have these conditions are recommended to use caution.

Side Effects

Call your doctor if you experience side effects that worry you or persist. Activella's side effects include back pain, headache, pain in the extremity, nausea, diarrhea, gastroenteritis, sleep problems, mood changes, upper respiratory tract infection, sinusitis, nasopharyngitis, weight gain, pain of the breast, post-menopausal bleeding, excessive uterine fibroid vaginal bleeding, ovarian cyst, thickening of the endometrium, viral infection, moniliasis genital, and accidental injury.

You can buy Activella at a competitive cost online and with a valid prescription at Canada Drugs Direct.

Reference:

Activella (estradiol/norethindrone acetate) tablets, for oral use. Plainsboro, NJ: Novo Nordisk Inc.; 2013.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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