Actimmune

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Actimmune (interferon gamma-1b) is a recombinant human interferon gamma indicated for the treatment of chronic granulomatous disease (CGD) and severe malignant osteopetrosis (SMO). In CGD, it reduces the frequency of serious infections by enhancing the microbial activity of phagocytes. In SMO, it is used to delay disease progression by modulating immune function and bone resorption. Actimmune exerts immunomodulatory, antiviral, and antiproliferative effects by inducing the expression of immune-regulatory genes and enhancing oxidative metabolism in phagocytes.

Fact Table

Formula

C769H1201N215O224S9

License

US FDA (1990)

Bioavailability

Subcutaneous: ~33%

Legal status

Prescription only

Chemical Name

Interferon gamma-1b

Elimination half-life

~5 hours

Dosage (Strength)

100 mcg (2 million IU)/0.5 mL injection solution

Pregnancy

Category C – Risk not ruled out

Brands

Actimmune

Protein binding

Not extensively bound (protein therapeutic)

PubChem CID

16131143

MedlinePlus

a604018

ChEBI

59578

ATC code

L03AB05

DrugBank

DB00033

KEGG

D02632

Routes of administration

Subcutaneous injection

Directions

Actimmune is administered by subcutaneous injection.

  • For CGD: The recommended dose is 50 mcg/m² (1 million IU/m²) three times weekly (e.g., Monday, Wednesday, Friday).
  • For SMO: The recommended dose is 50 mcg/m² (1 million IU/m²) three times weekly, reduced to 1/10th of the dose (1 mcg/kg) for very young infants or those with severe disease. Injection sites should be rotated to minimize local reactions. Dosing should be guided by body surface area and adjusted in pediatric populations. Therapy should be initiated and supervised by healthcare professionals experienced in immunodeficiency or metabolic bone disorders.

Ingredients

Active ingredient: interferon gamma-1b Inactive ingredients: mannitol, sodium succinate hexahydrate, succinic acid, polysorbate 20, and sterile water for injection (diluent supplied separately). The solution is preservative-free.

Contraindications

Actimmune is contraindicated in patients with:

  • Known hypersensitivity to interferon gamma-1b or any of its components
  • History of hypersensitivity reactions to E. coli-derived proteins

Cautions

Caution should be exercised in patients with pre-existing cardiac conditions, as transient flu-like symptoms (fever, chills) may exacerbate underlying disease. Hepatic function should be monitored due to the potential for elevated liver enzymes. Neurological effects including spasticity and gait disturbance have been reported, especially in patients with pre-existing central nervous system disorders. Use with caution in patients with bone marrow suppression or cytopenias. Regular monitoring of complete blood counts and liver function tests is recommended.

Side Effects

Common side effects may include:

  • Flu-like symptoms (fever, chills, fatigue)
  • Headache
  • Nausea
  • Vomiting
  • Myalgia
  • Injection site reactions
  • Anorexia
  • Elevated liver enzymes

Serious adverse effects may include hepatotoxicity, bone marrow suppression, neuropsychiatric symptoms, and hypersensitivity reactions.

IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet.

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