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Actemra (Tocilizumab)

Prescription medicineOnly Available By Prescription

What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Actemra (tocilizumab) is a prescription medication that is used for treating rheumatoid arthritis, giant cell arteritis, systemic sclerosis-associated interstitial lung disease, polyarticular juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis, cytokine release syndrome, and COVID-19.

Actemra comes as an injection that is to be administered subcutaneously. It is also available for intravenous (IV) infusion.

Fact Table






Tocilizumab is administered by injection and does not have a specific bioavailability value since it acts systemically

Legal status


Chemical Name


Elimination half-life

8–14 days during steady state (dependent on concentration)

Dosage (Strength)

Typically ranging from 162 mg to 324 mg


Consult Doctor


Actemra is the primary brand name for tocilizumab

Protein binding

Tocilizumab does not significantly bind to plasma proteins

PubChem CID

Not available




The ChEBI (Chemical Entities of Biological Interest) entry for tocilizumab is not available as it is a protein-based drug

ATC code






Routes of administration

Actemra is administered by intravenous infusion or subcutaneous injection


Actemra should be used as advised by your doctor. You may speak with your doctor or pharmacist if any questions or concerns arise.

Actemra dosing is dependent upon the condition being treated and your weight. Your doctor will also tell you if you should receive subcutaneous injections or the IV infusion.

Information regarding how to use Actemra, how much, and how often the medication should be administered will be provided to you by your doctor.


Tocilizumab is the active ingredient in Actemra.

L-arginine hydrochloride, L-histidine, L-histidine hydrochloride monohydrate, L-methionine, polysorbate 80, and water for Injection are the inactive ingredients in the subcutaneous injection.

Disodium phosphate dodecahydrate/sodium dihydrogen phosphate dihydrate buffered solution, polysorbate 80, sucrose, and water for Injection are the inactive ingredients in the IV formulation.


Patients who have an allergy to the Actemra should not receive it.


The following FDA Boxed Warnings are associated with Actemra:

  • Serious infections that can lead to hospitalization or result in death, including tuberculosis (TB), bacterial, invasive fungal, viral, and other opportunistic infections, have occurred in patients who were receiving Actemra.
  • If a serious infection occurs, Actemra should be stopped until the infection is under control.
  • Testing for latent TB should be performed. The exception is in patients with COVID-19. If the test result is positive, TB treatment should be started before initiating Actemra.
  • All patients should receive monitoring for TB during treatment, even if the latent TB test was negative.
  • Before you start using Actemra, talk to your doctor about:
    • All prescription and over-the-counter medications you take
    • Any allergies you have
    • Your past medical history and current health issues
    • Your pregnancy or breastfeeding status
  • Actemra may cause gastrointestinal perforation. Caution should be used in patients who are at increased risk.
  • Liver damage may occur during treatment with Actemra. Patients should seek immediate medical care if they have fatigue, weight loss, abdominal pain, dark urine, or yellowing of the skin or whites of the eyes.
  • It is recommended to monitor neutrophils, platelets, lipids, and liver function labs since Actemra can cause changes in these tests.
  • Hypersensitivity reactions, including anaphylaxis and death, can occur during treatment with Actemra.
  • Patients who are currently on Actemra should not receive live vaccines.

Side Effects

Upper respiratory tract infections, nasopharyngitis, headache, high blood pressure, increased liver function tests, and injection site reactions are the most common Actemra side effects that can occur.

Looking to buy Actemra online at a competitive price? With a valid prescription from your doctor, you can at Canada Drugs Direct.


Actemra. South San Francisco, CA: Genentech Inc.; 2022.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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