Accolate (Zafirlukast)

Description

Accolate (Zafirlukast) is a prescription medication classified as a leukotriene receptor antagonist. It is used to help control asthma symptoms in individuals aged 5 years and older. Zafirlukast works by blocking the action of certain chemicals in the body that cause inflammation in the airways, thus reducing asthma symptoms. Accolate is not intended for relieving an ongoing asthma attack, but rather for preventing future episodes.

Directions

The usual dosage for Accolate is 20 mg administered orally twice daily in people 12 years and older. The standard dosage in children aged 5 to 11 is 10 mg twice daily. Adults over 65 may need dosage adjustments due to the risk of side effects. This medication should be taken at least 1 hour before or 2 hours after meals, maintaining regular intervals between doses. Follow the prescribed dosage and schedule provided by your healthcare provider.

Ingredients

The film-coated tablets of Accolate comprise both active and inactive ingredients. The active ingredient in the medication is Zafirlukast, which plays a role in managing asthma symptoms. The inactive ingredients may include croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, povidone, hypromellose, and titanium dioxide. These inactive ingredients serve as excipients and ensure proper absorption and function of the active ingredient.

Contraindications

Avoid taking or using Accolate if any of the following apply:

• You have a known or suspected allergy to Accolate or any of its ingredients.
• You have a diagnosed liver condition, such as cirrhosis, as this medication may worsen symptoms of your condition.

Cautions

• Before taking Zafirlukast, consult your healthcare provider about the following:
• Existing medical conditions, especially liver problems
• Any medications you are currently taking, as there might be possible drug interactions
• If you are pregnant, planning to become pregnant, or breastfeeding
• There's a chance Accolate could lead to liver issues. Should you experience symptoms like pain in the upper right side of your abdomen, unusual tiredness, or a yellowing of the eyes or skin, reach out to your healthcare professional.
• Accolate is designed for consistent treatment over time. It isn't meant for immediate relief during acute episodes. Continue with other prescribed treatments unless told otherwise.
• For those breastfeeding, it's recommended to avoid Accolate. Explore different treatment options with your doctor.
• For the best effect, take Accolate either an hour before eating or two hours post-meal.
• Some patients on treatments akin to Accolate have experienced symptoms similar to Churg-Strauss syndrome. Be vigilant for signs such as skin rashes, worsening lung issues, or heart-related problems.
• Medications of this kind have occasionally been associated with mental health disturbances, including sleeplessness and feelings of depression. If these or similar symptoms arise, it's important to communicate with your healthcare provider.

Side Effects

The use of Accolate can result in various adverse reactions. Frequent side effects associated with Accolate may include headaches, nausea, upset stomach, and abdominal discomfort. Some individuals might also encounter dizziness, aches in the muscles, pain in the back, digestive issues, and symptoms of a cold like nasal congestion, sneezing, and a scratchy throat. While these common reactions typically aren’t serious health threats, it may be important to keep an eye on their intensity or how often they occur.

In rare instances, Accolate may trigger critical health problems requiring urgent medical care. Such side effects can include liver-related issues, manifesting as a lack of appetite, abdominal discomfort in the upper right area, exhaustion, itchiness, dark-colored urine, and a yellowish skin tone. If any serious side effects arise, consult a medical professional immediately.

References:

1. Accolate (Zafirlukast) Product Monograph. Wilmington, DE: AstraZeneca Pharmaceuticals; 2013.

Accolate (Zafirlukast) Drug Label Information. Chestnut Ridge, NY: Par Pharmaceutical, Inc.; 2015.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....