Abilify Maintena (Aripiprazole)

Description

Abilify Maintena (Aripiprazole) is an antipsychotic medication used to treat adults with schizophrenia and bipolar disorder. It works by balancing the dopamine and serotonin levels in the brain, which may help improve thoughts, mood, and behavior. As a once-monthly injectable drug, Abilify Maintena may help simplify treatment plans while maintaining consistent results.

Directions

Abilify Maintena (Aripiprazole) is an extended-release injection administered by a healthcare provider, typically at a doctor's office or a hospital. The standard recommended Abilify Maintena dosing is 400 mg once monthly. For those without a history of Aripiprazole use, it is necessary to establish tolerability with oral Aripiprazole for up to two weeks before starting treatment with the injection. The injection is administered in either the shoulder or buttocks.

Ingredients

The main ingredient in Abilify Maintena is Aripiprazole, which belongs to the class of atypical antipsychotics. The injectable suspension of Abilify Maintena may contain inactive ingredients to preserve and stabilize the medication.

Contraindications

Those who have experienced an allergic reaction or hypersensitivity to Aripiprazole or any of the ingredients found in the Abilify Maintena injection should avoid using the medication.

Cautions

• Before starting treatment with Abilify Maintena, inform your doctor or healthcare provider about:
• Any medications you take, especially blood pressure medications, benzodiazepines, and seizure medications
• Existing medical conditions you have, as some may be worsened by this medication
• If you are pregnant or plan to become pregnant, as the effects on unborn babies are unknown
• If you are breastfeeding or plan to breastfeed, as Aripiprazole may pass into breast milk and potentially affect your baby
• Elderly patients might face a higher risk of adverse effects related to the brain, such as strokes. Some cases have been fatal.
• Seek immediate medical attention if you notice symptoms like intense fever or stiff muscles, as they could be signs of NMS.
• Uncontrolled, spontaneous movements might develop while on the medication. Should these emerge, consult a doctor about discontinuing the medication.
• Potential metabolic side effects of Abilify Maintena include increased blood sugar levels, changes in cholesterol levels, and weight changes. Keep an eye out for increased thirst, hunger, or frequent trips to the restroom.
• Sudden and strong urges, like compulsive gambling, could develop. Consult a healthcare provider for potential changes in the medication dosage or discontinuation of the medication.
• This medication may cause a decrease in blood pressure levels when getting up from a sitting or lying position.
• History of low white blood cell counts often requires routine blood tests. If there's an unexplained decrease, a healthcare provider may alter or change the medication.
• If seizures have been a problem in the past, extra vigilance is required when using Abilify Maintena.
• Activities demanding clear thinking or precise motor control, like driving, could be affected while on Abilify Maintena.

Side Effects

Abilify Maintena may cause side effects. The most common Abilify Maintena side effects may include inner restlessness (akathisia), drowsiness, weight gain, and pain at the injection site. Other side effects may vary. Consult a healthcare provider if side effects develop, persist, or worsen.

More serious side effects of Abilify Maintena may require immediate medical attention. These can include an increased risk of stroke and ministroke, especially in elderly people with dementia-related psychosis, and neuroleptic malignant syndrome (NMS), a serious condition that can potentially lead to death. If someone taking Abilify Maintena experiences any of these severe side effects, it is crucial to seek medical advice promptly.

References:

Abilify Maintena (Aripiprazole) Highlights of Prescribing Information. Tokyo, JP: Otsuka America Pharmaceutical, Inc; 2023.

About Dr. Gerardo Sison (Page Author)

An honors graduate of the University of Florida, Dr. Sison started his pharmacy career in a community setting, extending his services to hospitals and clinics over time. He has also worked in medication therapy management, advising patients on proper medication use for their chronic health conditions. Read More....