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Ozempic (Semaglutide)

Prescription medicineOnly Available By Prescription
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Strength Pack Size Qty
Strength
2mg (0.25/0.5mg per dose)
Pack Size
Qty
Strength
4mg (1mg per dose)
Pack Size
Qty

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Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Ozempic

Used with diet and exercise, Ozempic (semaglutide) is an injectable medication for the treatment of type 2 diabetes in adults. Ozempic is also used to lower the risk of heart attack, stroke, or cardiovascular death in adult patients with type 2 diabetes and heart disease.

Ozempic may help with weight loss, but it is not indicated for weight loss.


Fact Table

Formula

C187H291N45O59

License

EU EMA, US FDA

Bioavailability

89%

Legal status

Rx-Only

Chemical Name

Semaglutide

Elimination half-life

7 days

Dosage (Strength)

2mg (0.25/0.5mg per dose), 4mg (1 mg per dose) (Pen Injector)

Pregnancy

Should not be used

Brands

Ozempic

Protein binding

More than 99%

PubChem CID

56843331

MedlinePlus

a618008

ChEBI

167574

ATC code

A10BJ06

DrugBank

DB13928

KEGG

D10025

Routes of administration

Subcutaneous

Directions

Ozempic is supplied in single-patient-use pens:

  • 2 mg/1.5 mL (1.34 mg/mL): delivers 0.25 mg, 0.5 mg, or 1 mg per injection
  • 4 mg/3 mL(1.34 mg/mL): delivers 1 mg per injection

Be sure to read and follow the instructions that come with your prescription. If you are unsure how to administer Ozempic or if you have any other questions or concerns, talk to your doctor or pharmacist.

Starting dose: 0.25 mg injected subcutaneously into the abdomen, thigh, or upper arm once weekly. Ozempic can be administered with or without food. After 4 weeks, your dose may be increased to 0.5 mg once weekly. Your doctor may choose to increase your dose to 1 mg once weekly depending on your tolerance and response to the medication.

You should rotate your Injection sites each week.

If you miss your dose, you may administer it within 5 days of the missed dose.

Unused Ozempic pens without an attached needle may be stored in the refrigerator until the expiration date. Used Ozempic pens without an attached needle may be stored at room temperature or in the refrigerator until the expiration date or for 56 days, whichever occurs first. Ozempic pens should not be stored in the freezer. 

Use a new needle for each injection. An Ozempic pen should never be shared, even if it has a new needle. After each injection, dispose of used needles in a sharps disposal container.

Ingredients

Semaglutide is the active ingredient in Ozempic.

Contraindications

Avoid the use of Ozempic if you or a family member has had medullary thyroid carcinoma, a type of thyroid cancer. 

Avoid the use of Ozempic if you have Multiple Endocrine Neoplasia syndrome type 2.

Avoid the use of Ozempic if you are allergic to semaglutide or any of its ingredients or excipients.

Cautions

WARNING: RISK OF THYROID C-CELL TUMORS

See full prescribing information for complete boxed warning.

  • In rodents, semaglutide causes thyroid C-cell tumors. It is unknown whether OZEMPICĀ® causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.
  • OZEMPICĀ® is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk of MTC and symptoms of thyroid tumors.

  • Before your treatment with Ozempic starts, inform your doctor:
    • Of all the medications you take, including prescription, over-the-counter, vitamins, and herbal supplements. 
    • Of your allergies.
    • Of your medical conditions.
    • Of your pregnancy status.
    • Of your breastfeeding status.
  • Pancreatitis can occur with the use of Ozempic. Get emergency care right away if you experience severe stomach pain that doesn't go away. The pain may extend to your back, with or without the presence of vomiting.
  • Complications of diabetic retinopathy can occur with the use of Ozempic. Inform your doctor immediately of any vision changes or problems.
  • Low blood sugar levels can occur if Ozempic is used with an insulin secretagogue or insulin. Check your blood sugar and treat low blood sugar levels as directed by your doctor.
  • Kidney problems can occur with the use of Ozempic.
  • Severe allergic reactions can occur with the use of Ozempic. Get emergency care right away if you experience breathing problems, issues swallowing, swelling of your face, lips, or tongue, a serious rash, itching, fainting, or a quickened heart rate.

Side Effects

Ozempic can cause side effects, including constipation, diarrhea, nausea, vomiting, and stomach pain. These are not all of the side effects. Tell your doctor right away if you experience bothersome or persistent side effects.

Ozempic (Semaglutide) Frequently Asked Questions

Click the links below to jump to the section of the FAQ you want to learn more about.

  1. Am I a Good Candidate to Switch to Ozempic?
  2. How Does Ozempic Work?
  3. How Do I Take Ozempic?
  4. Is Ozempic Proven to Lower A1C?
  5. Does Ozempic Help with Weight Loss for Type 2 Diabetes?
  6. How Much Does Ozempic Cost?
  7. What Sort of Diet Changes and Exercise are Required with Ozempic?
  1. Am I a Good Candidate to Switch to Ozempic?

Ozempic is effective for lowering blood sugar and A1C hemoglobin test scores for most people. Type 2 diabetics that are more at risk of cardiovascular failure, heart attack, or stroke because of their diabetes are ideal candidates to switch to Ozempic.

Better diabetes management with Ozempic is dependent on diet and exercise level changes to go along with using Semaglutide. Ozempic is not for weight loss, but some users may see better results from the increased physical activity levels that are a part of treatment with this medication.

Meeting with your physician is the first step to seeing if Ozempic is a better choices as your diabetes medication.

  1. How Does Ozempic Work?

Ozempic is a non-insulin diabetes medication that work with the body's natural ability to lower blood sugar and get A1c scored down below the standard 7% threshold. It is designed to begin working when your blood sugar rises, and it promotes the pancreas releasing more insulin when blood sugar levels are up.

Ozempic also prevents the liver from producing and releasing higher levels of glucose. The last part of how Ozempic works is that it slows down food leaving the stomach.

  1. How Do I Take Ozempic?

Ozempic is a once-weekly diabetes medication delivered with the Ozempic pen. The injection is administered under the skin (subcutaneously) of the stomach (abdomen, thigh, or upper arm).

These are the only three administration sites. Injection should not be made into a muscle (intramuscularly) or into a vein (intravenously).

  1. Is Ozempic Proven to Lower A1C?

Ozempic users commonly see better results in their A1C test scores, but results will vary for people based on different factors. It is important to follow your diabetes treatment regimen exactly as it is laid out for by your doctor, and Ozempic users need to incorporate diet and exercise changes to see best results.

  • Of adults with an average starting A1C of 8.1%, 66% of those taking 0.5mg Ozempic reached an A1C of 7% or less
  • 73% of those taking 1mg and 40% of people taking 100mg Januvia for Type 2 diabetes did the same - getting to an A1C of 7% or lower
  1. Does Ozempic Help with Weight Loss for Type 2 Diabetes?

It is important to understand that Ozempic is not indicated for weight loss. Increased weight loss may be benefit for some people using Ozempic, and especially those who adhere to the diet and exercise part of using this medication. Keep in mind that some study participants using Ozempic experienced weight gain, although this is uncommon.

For people with an average starting weight of 197 pounds

  • 0.5mg Ozempic users lost an average of 9 pounds
  • 1mg Ozempic users lost an average of 12 pounds
  • 100mg Januvia users lost an average of 4 pounds

Based on a 1-year study

  1. How Much Does Ozempic Cost?

Your Ozempic price will depend on the pharmacy and whether you are filling a prescription for the 0.5mg or 1mg Ozempic pen. Many people in North America will be able to buy diabetic medication with a co-pay arrangement through their health benefits. US residents may want to consider applying for the Ozempic savings card made available by Novo Nordisk.

You also may be able to buy Ozempic for less when you order medication online from Canada Drugs Direct.

  1. What Sort of Diet Changes and Exercise are Required with Ozempic?

Best results from Ozempic for Type 2 diabetes are seen in users who eat a healthier diet with lower glycemic loads per meal and significant reductions in sugar intake via diet. Increased exercise / physical activity levels should be discussed with your doctor before starting on a Type 2 diabetes treatment medication. For most people 30 minutes of upbeat cardiovascular exercise (anything that gets your heart rate up and makes you break a sweat) 3 times a week is a good baseline to start at.

If you are beginning physical exercise for the first time it is important to go slow and steady in the beginning, and this is true for people of all ages.

References:

  1. Ozempic semaglutide injection. Plainsboro, NJ: Novo Nordisk Inc.; 2021.
  2. Once-weekly Ozempic semaglutide injection. Important Safety Information. https://www.ozempic.com. Accessed March 14, 2022.



IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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