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Osmolex ER (Amantadine)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada.
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda.
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Osmolex ER is a drug that your doctor may prescribe for movement disorders like Parkinson's disease or drug-induced extrapyramidal reactions in adults.

Parkinson's disease is a disorder of the nervous system that affects movement. It can affect different parts of the body and damage nerve cells in the brain. It typically starts with a hand tremor (shaking) and progresses to other movement symptoms like stiffness, loss of balance, and slow movement.

Extrapyramidal reactions are caused by the long-term use of antipsychotic drugs for conditions like bipolar disorder and schizophrenia.

Fact Table







Legal status


Chemical Name


Elimination half-life

10–31 hours

Dosage (Strength)

129 mg, 193 mg, 258 mg


Consult Doctor


Osmolex ER

Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The dosage of Osmolex ER usually starts with 129 mg once daily in the morning. Your healthcare provider may increase it to a maximum daily dosage of 322 mg once daily in the morning.

Do not crush, chew, or split the tablets.


The active ingredient in Osmolex ER is amantadine extended-release.


There are many drug-drug interactions with this medication, including:

  • Alcohol 
  • Alkalinizing Agents
  • Amisulpride 
  • Anticholinergic Agents
  • Aripiprazole
  • Brivudine 
  • BuPROPion
  • Carbonic Anhydrase Inhibitors
  • Clozapine
  • Erdafitinib
  • Fluphenazine
  • Glycopyrrolate 
  • Haloperidol
  • Influenza vaccine
  • Kava Kava
  • Memantine
  • Methotrimeprazine
  • Methylphenidate
  • Metoclopramide
  • Quetiapine
  • QuiNIDine
  • Sulpiride
  • Trimethoprim
  • Ziprasidone


This drug may cause you to fall asleep during daily activities.

Tell your healthcare team if you have increased suicidal thoughts, depression, or anxiety while taking this drug.

This drug may increase dizziness and drowsiness while taking it.

Side Effects

Common Osmolex ER side effects with this drug may include:

  • Abnormal dreams
  • Agitation
  • Anorexia
  • Anxiety
  • Apathy
  • Ataxia
  • Benign prostatic hypertrophy
  • Blurred vision
  • Bruise
  • Cataract
  • Constipation
  • Cough
  • Decreased appetite
  • Delusions
  • Depression
  • Diarrhea
  • Dizziness
  • Drowsiness
  • Dry nose
  • Falling
  • Fatigue
  • Hallucinations
  • Headache
  • Illusion
  • Insomnia
  • Irritability
  • Joint swelling
  • Muscle spasm
  • Nausea
  • Nervous
  • Orthostatic hypotension
  • Paranoia
  • Peripheral edema
  • Presyncope
  • Suicidal ideation
  • Urinary tract infection
  • Vomiting
  • Xerostomia


Osmolex ER. Bridgewater, NJ: Vertical Pharmaceuticals; February 2018.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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