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Top brand choice
Strength | Pack Size | Qty | |
---|---|---|---|
Strength
10mg
|
We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!
Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.
To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.
Terms & Conditions of Program
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Letairis is a prescription medication used to treat pulmonary arterial hypertension (PAH), which is characterized by high blood pressure in the arteries that supply the lungs.
Letairis belongs to a class of drugs known as endothelin receptor antagonists, which block the action of endothelin, which causes blood vessels to narrow. Endothelin proteins are located on vascular endothelium and smooth muscle.
Fact Table | |
Formula |
C22H22N2O4 |
License |
US FDA, EU EMA |
Bioavailability |
Undetermined |
Legal status |
Rx-Only |
Chemical Name |
Ambrisentan |
Elimination half-life |
15 hours (terminal) |
Dosage (Strength) |
10mg |
Pregnancy |
Consult Doctor |
Brands |
Letairis |
Protein binding |
99% |
PubChem CID |
6918493 |
MedlinePlus |
a612023 |
ChEBI |
135949 |
ATC code |
C02KX02 |
DrugBank |
C02KX02 |
KEGG |
D07077 |
Routes of administration |
By mouth |
The usual dosage starts with 5 mg by mouth once daily. The dosage can be increased every four weeks based on side effects and response to treatment.
Do not split, crush, or chew the tablets.
The active ingredient in Letairis is Ambrisentan.
Common drug-drug interactions can include:
Letairis should not be taken during pregnancy due to the risk of fetal harm. Women of childbearing age should use contraception during treatment and after stopping Letairis.
Tell your doctor if you have a history of liver problems because Letairis can cause serious liver injury. Regular liver function tests should be conducted during treatment to monitor liver health.
Tell your healthcare provider if you have a history of heart failure. Letairis may cause fluid retention or swelling.
Do not take this medication if you have a history of idiopathic pulmonary fibrosis.
Male patients may experience a decreased sperm count while taking this drug.
Tell your doctor if you have a history of anemia. They should regularly monitor your blood counts while taking Letairis.
The most common adverse effects can include:
Letairis [package insert]. Foster City, CA: Gilead; 2019.