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Letairis (Ambrisentan)

Prescription medicineOnly Available By Prescription

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What if I find a lower price with another pharmacy?

We guarantee the lowest price on all of our prescription products. If you find your medications cheaper at any other recognized licensed mail order pharmacy, we will not only match their price, we will beat it by 25% of the difference. It is our 125% price match guarantee!

Example: If you find a product on Canada Drugs Direct for $50.00 and find the same product for $40.00 at another mail order pharmacy, we will provide you with a $12.50 discount, bringing your total to $37.50.

To get the discount please make sure to mention the price match to the customer service team when they call to collect payment for your order. Or call toll free at 1-888-904-8467 to place the order through the phone.

Terms & Conditions of Program

  • Guaranteed lowest price is only valid at the time of sale.
  • We will only match the current advertised price.
  • Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. The must be a member of CIPA (Canadian International Pharmacy Association).
  • Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
  • Products must be new. We cannot match the price of any used, short expiry or expired product.
  • Price match can only be issued over the phone with our customer service team
What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.


Letairis is a prescription medication used to treat pulmonary arterial hypertension (PAH), which is characterized by high blood pressure in the arteries that supply the lungs.

Letairis belongs to a class of drugs known as endothelin receptor antagonists, which block the action of endothelin, which causes blood vessels to narrow. Endothelin proteins are located on vascular endothelium and smooth muscle.

Fact Table







Legal status


Chemical Name


Elimination half-life

15 hours (terminal)

Dosage (Strength)



Consult Doctor



Protein binding


PubChem CID






ATC code






Routes of administration

By mouth


The usual dosage starts with 5 mg by mouth once daily. The dosage can be increased every four weeks based on side effects and response to treatment.

Do not split, crush, or chew the tablets.


The active ingredient in Letairis is Ambrisentan.


Common drug-drug interactions can include:

  • CycloSPORINEs
  • Darolutamide
  • Eltrombopag
  • Encorafenib
  • Gemfibrozil
  • Leflunomide
  • Leniolisib
  • Pretomanid
  • Sparsentan
  • Teriflunomide
  • Trofinetide
  • Voclosporin


Letairis should not be taken during pregnancy due to the risk of fetal harm. Women of childbearing age should use contraception during treatment and after stopping Letairis.

Tell your doctor if you have a history of liver problems because Letairis can cause serious liver injury. Regular liver function tests should be conducted during treatment to monitor liver health.

Tell your healthcare provider if you have a history of heart failure. Letairis may cause fluid retention or swelling.

Do not take this medication if you have a history of idiopathic pulmonary fibrosis.

Male patients may experience a decreased sperm count while taking this drug.

Tell your doctor if you have a history of anemia. They should regularly monitor your blood counts while taking Letairis.

Side Effects

The most common adverse effects can include:

  • Anemia
  • Bronchitis
  • Cardiac failure
  • Cough
  • Decreased hematocrit
  • Decreased hemoglobin
  • Dizziness
  • Dyspepsia
  • Fatigue
  • Flushing
  • Fluid retention
  • Headache
  • Hypersensitivity
  • Hypotension
  • Increased liver enzymes
  • Nasal congestion
  • Nausea
  • Oligospermia
  • Peripheral edema
  • Sinusitis
  • Vomiting
  • Weakness


Letairis [package insert]. Foster City, CA: Gilead; 2019.

IMPORTANT NOTE: The above information is intended to increase awareness of health information and does not suggest treatment or diagnosis. This information is not a substitute for individual medical attention and should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. See your health care professional for medical advice and treatment.

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